Evidence map›Paper›PMID 29110996›Full record

Trial reportHeart rhythm2017

Atrial ectopy as a mediator of the association between race and atrial fibrillation.

Matthew A Christensen, Kaylin T Nguyen, Phyllis K Stein, Raymond B Fohtung, Elsayed Z Soliman, Thomas A Dewland, Eric Vittinghoff, Bruce M Psaty, Susan R Heckbert, Gregory M Marcus

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Heart rhythm, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Social determinants of atrial fibrillation.Nature reviews. Cardiology · 2021
    Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Matthew A ChristensenElectrophysiology Section, Division of Cardiology, Department of Medicine, University of California, San Francisco, California; University of Michigan Medical School, Ann Arbor, Michigan.
Kaylin T NguyenElectrophysiology Section, Division of Cardiology, Department of Medicine, University of California, San Francisco, California.
Phyllis K SteinDivision of Cardiology, Department of Medicine, Washington University, St. Louis, Missouri.
Raymond B FohtungDepartment of Medicine, Washington University, St. Louis, Missouri.
Elsayed Z SolimanDepartment of Epidemiology and Prevention, Wake Forest University, Winston Salem, North Carolina.
Thomas A DewlandKnight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon.
Eric VittinghoffDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.
Bruce M PsatyCardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Sciences, University of Washington, Seattle, Washington.
Susan R HeckbertGroup Health Research Institute, Group Health Cooperation, Seattle, Washington.
Gregory M MarcusElectrophysiology Section, Division of Cardiology, Department of Medicine, University of California, San Francisco, California. Electronic address: marcusg@medicine.ucsf.edu.
University of California, San Francisco · USWashington University in St. Louis · USGroup Health Cooperative · USOregon Health & Science University · USUniversity of Michigan–Ann Arbor · USUniversity of Washington · USWake Forest University · US

Funding

Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5M
CHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6M
CHS Events Follow-up StudyU01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2005 to 2008
$4.6M
Promoting Research Opportunities Fully--Prospective Academics Transforming HealthR25MD006832 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ARONSON, LOUISE, FERNANDEZ, ALICIA · 2011 to 2015
$1.7M
CORONARY HEART DISEASE AND STROKE IN PEOPLE AGED 65-84N01HC085082 · HC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KULLER, LEWIS H · 1988 to 2000
–
CHS-Transition Phase -268055222-268055222N01HC055222 · HC · UNIVERSITY OF WASHINGTON · PI KRONMAL, RICHARD A · 2005 to 2006
–
CENTRAL BLOOD ANALYSIS LABORATORY FOR CHSN01HC085086 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1988 to 2000
–
CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84N01HC085083 · HC · UNIVERSITY OF CALIFORNIA DAVIS · PI ROBBINS, JOHN A · 1988 to 1999
–
CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65 TO 84N01HC085079 · HC · UNIVERSITY OF WASHINGTON · 1988 to 2005
–
CORONARY HEART DISEASE &STROKE IN THE ELDERLYN01HC085080 · HC · WAKE FOREST UNIVERSITY · PI BURKE, GREGORY L · 1988 to 2000
–
CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84N01HC085081 · HC · JOHNS HOPKINS UNIVERSITY · PI FRIED, LINDA P · 1988 to 2000
–
NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIA NIH HHS R01 AG023629NIMHD NIH HHS R25 MD006832
6 · The paper itself

Abstract

backgroundBlacks have a lower risk of atrial fibrillation (AF) despite having more AF risk factors, but the mechanism remains unknown. Premature atrial contraction (PAC) burden is a recently identified risk factor for AF.

objectiveThe purpose of this study was to determine whether the burden of PACs explains racial differences in AF risk.

methodsPAC burden (number per hour) was assessed by 24-hour ambulatory electrocardiographic (ECG) monitoring in a randomly selected subset of patients in the Cardiovascular Health Study. Participants were followed prospectively for the development of AF, diagnosed by study ECG and hospital admission records.

resultsAmong 938 participants (median age 73 years; 34% black; 58% female), 206 (22%) developed AF over a median follow-up of 11.0 years (interquartile range 6.1-13.4). After adjusting for age, sex, body mass index, coronary disease, congestive heart failure, diabetes, hypertension, alcohol consumption, smoking status, and study site, black race was associated with a 42% lower risk of AF (hazard ratio 0.58, 95% confidence interval [CI] 0.40-0.85; P = .005). The baseline PAC burden was 2.10 times (95% CI 1.57-2.83; P <.001) higher in whites than blacks. There was no detectable difference in premature ventricular contraction (PVC) burden by race. PAC burden mediated 19.5% (95% CI 6.3-52.5) of the adjusted association between race and AF.

conclusionOn average, whites exhibited more PACs than blacks, and this difference statistically explains a modest proportion of the differential risk of AF by race. The differential PAC burden, without differences in PVCs, by race suggests that identifiable common exposures or genetic influences might be important to atrial pathophysiology.

Indexed as

EthnicityRisk AssessmentAgedAtrial FibrillationAtrial Premature ComplexesElectrocardiography, AmbulatoryFemaleFollow-Up StudiesHeart AtriaHeart RateHumansIncidenceMalePrognosisProspective StudiesRisk FactorsArrhythmiaAtrial fibrillationAtrial premature beatPremature atrial contractionRace

Identifiers

PMID29110996
PMCPMC5712237
OpenAlexW2766553146

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.