ArticleInternational journal of geriatric psychiatry2018
Amotivation is associated with smaller ventral striatum volumes in older patients with schizophrenia.
Article in International journal of geriatric psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Data-driven schizophrenia subtyping via brain atrophy trajectories and functional connectivity.Translational psychiatry · 2026Article
- Orbitofrontal Thickness and Network Associations as Transdiagnostic Signature of Amotivation Along the Bipolar-Schizophrenia Spectrum.Schizophrenia bulletin · 2026Article
- Cortical thinning in relation to impaired insight into illness in patients with treatment resistant schizophrenia.Schizophrenia (Heidelberg, Germany) · 2023Article
- The Impact of Antipsychotic Treatment on Neurological Soft Signs in Patients with Predominantly Negative Symptoms of Schizophrenia.Biomedicines · 2022Article
- Negative symptom dimensions and social functioning in Chinese patients with schizophrenia.Frontiers in psychiatry · 2022Article
- Orbitofrontal-Striatal Structural Alterations Linked to Negative Symptoms at Different Stages of the Schizophrenia Spectrum.Schizophrenia bulletin · 2021Article
- Trait impulsivity is not related to post-commissural putamen volumes: A replication study in healthy men.PloS one · 2018Article
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15 authors.
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Abstract
objectiveMotivational deficits are prevalent in patients with schizophrenia, persist despite antipsychotic treatment, and predict long-term outcomes. Evidence suggests that patients with greater amotivation have smaller ventral striatum (VS) volumes. We wished to replicate this finding in a sample of older, chronically medicated patients with schizophrenia. Using structural imaging and positron emission tomography, we examined whether amotivation uniquely predicted VS volumes beyond the effects of striatal dopamine D
methodsData from 41 older schizophrenia patients (mean age: 60.2 ± 6.7; 11 female) were reanalysed from previously published imaging data. We constructed multivariate linear stepwise regression models with VS volumes as the dependent variable and various sociodemographic and clinical variables as the initial predictors: age, gender, total brain volume, and antipsychotic striatal D
resultsAmotivation uniquely explained 8% and 6% of the variance in right and left VS volumes, respectively (right: β = -.38, t = -2.48, P = .01; left: β = -.31, t = -2.17, P = .03). Considering cognition, amotivation levels uniquely explained 9% of the variance in right VS volumes (β = -.43, t = -0.26, P = .03).
conclusionWe replicate and extend the finding of reduced VS volumes with greater amotivation. We demonstrate this relationship uniquely beyond the potential contributions of striatal D
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