Evidence map›Paper›PMID 29110194›Full record

ArticleBrain imaging and behavior2018

White matter fiber bundle lengths are shorter in cART naive HIV: an analysis of quantitative diffusion tractography in South Africa.

Jodi M Heaps-Woodruff, John Joska, Ryan Cabeen, Laurie M Baker, Lauren E Salminen, Jacqueline Hoare, David H Laidlaw, Rachel Wamser-Nanney, Chun-Zi Peng, Susan Engelbrecht and 3 more

Abstract read
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In one paragraph

Article in Brain imaging and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jodi M Heaps-WoodruffMissouri Institute of Mental Health, University of Missouri, St. Louis, MO, USA. heapsj@umsl.edu.
John JoskaDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Ryan CabeenLaboratory of Neuro Imaging, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
Laurie M BakerMissouri Institute of Mental Health, University of Missouri, St. Louis, MO, USA.
Lauren E SalminenMark and Mary Stevens Neuroimaging and Informatics Institute, Imaging Genetics Center, University of Southern California, Los Angeles, CA, USA.
Jacqueline HoareDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
David H LaidlawLaboratory of Neuro Imaging, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
Rachel Wamser-NanneyDepartment of Psychology, University of Missouri-St. Louis, St. Louis, MO, USA.
Chun-Zi PengMissouri Institute of Mental Health, University of Missouri, St. Louis, MO, USA.
Susan EngelbrechtDivision of Medical Virology, Stellenbosch University and National Health Laboratory Services (NHLS), Cape Town, South Africa.
Soraya SeedatDivision of Medical Virology, Stellenbosch University and National Health Laboratory Services (NHLS), Cape Town, South Africa.
Dan J SteinMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, University of Stellenbosch, Stellenbosch, South Africa.
Robert H PaulMissouri Institute of Mental Health, University of Missouri, St. Louis, MO, USA.

Funding

Neuropathogenesis of clade C HIV in South AfricaR01MH085604 · NIMH · UNIVERSITY OF MISSOURI-ST. LOUIS · PI PAUL, ROBERT HARRIS · 2009 to 2013
$2.9M
Diffusion Tensor Imaging and Neuropsychological Outcomes in HIV/HCV Co-infectionF31NS070706 · NINDS · UNIVERSITY OF MISSOURI-ST. LOUIS · PI HEAPS-WOODRUFF, JODI M · 2010 to 2012
$77k
National Institute of Mental Health R01MH085604NIMH NIH HHS R01 MH085604NINDS NIH HHS F31 NS070706
6 · The paper itself

Abstract

This study examines white matter microstructure using quantitative tractography diffusion magnetic resonance imaging (qtdMRI) in HIV+ individuals from South Africa who were naïve or early in the initiation of antiretroviral therapy. Fiber bundle length (FBL) metrics, generated from qtdMRI, for whole brain and six white matter tracts of interest (TOI) were assessed for 135 HIV+ and 21 HIV- individuals. The association between FBL metrics, measures of disease burden, and neuropsychological performance were also investigated. Results indicate significantly reduced sum of whole brain fiber bundle lengths (FBL, p < 0.001), but not average whole brain FBL in the HIV+ group compared to the HIV- controls. The HIV+ group exhibited significantly shorter sum of FBL in all six TOIs examined: the anterior thalamic radiation, cingulum bundle, inferior and superior longitudinal fasciculi, inferior frontal occipital fasciculus, and the uncinate fasciculus. Additionally, average FBLs were significantly shorter select TOIs including the inferior longitudinal fasciculus, cingulum bundle, and the anterior thalamic radiation. Shorter whole brain FBL sum metrics were associated with poorer neuropsychological performance, but were not associated with markers of disease burden. Taken together these findings suggest HIV affects white matter architecture primarily through reductions in white matter fiber numbers and, to a lesser degree, the shortening of fibers along a bundle path.

Indexed as

Diffusion Tensor ImagingAdultFemaleHIV InfectionsHumansImage Processing, Computer-AssistedMaleMiddle AgedNerve Fibers, MyelinatedNeural PathwaysOrgan SizeSouth AfricaWhite MatterYoung AdultCognitionDiffusion tensor imagingHIVQuantitative tractography

Identifiers

PMID29110194
PMCPMC5936682

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.