ArticleProgress in biomaterials2017
New formulation and approach for mucoadhesive buccal film of rizatriptan benzoate.
Article in Progress in biomaterials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Design, optimization and characterization of mucoadhesive buccal film as a novel delivery system for doxazosin mesylate.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2026Article
- Cellulose-Based Polymer Blends for Oral Mucoadhesion: Impact of Hydration and Surface Interactions.Polymers · 2026Article
- Evaluation of a multi-component mucoadhesive buccal patch: cytokine-associated inflammatory responses and tissue remodeling in experimental models.Frontiers in immunology · 2026Article
- Fast-Dissolving Pullulan Film as a Solid Dosage Form for Sublingual Administration of Nifedipine-Loaded Nanocapsules.AAPS PharmSciTech · 2025Article
- Design and Evaluation of Instant Release Buccal Films of Empagliflozin: A Statistical Approach.ACS omega · 2025Article
- Development and Optimization of Chitosan-Ascorbate-Based Mucoadhesive Films for Buccal Delivery of Captopril.Pharmaceutics · 2025Article
- Complexation of α-Mangostin with γ-Cyclodextrin and Its Application in Alginate/Chitosan Hydrogel Mucoadhesive Film for Treatment of Recurrent Aphthous Stomatitis.Journal of inflammation research · 2025Article
- Migraine and Its Treatment from the Medicinal Chemistry Perspective.ACS pharmacology & translational science · 2024Review
- Statistically Optimized Polymeric Buccal Films of Eletriptan Hydrobromide and Itopride Hydrochloride: An In Vivo Pharmacokinetic Study.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Formulation and Characterization of Mucoadhesive Polymeric Films Containing Extracts of Taraxaci Folium and Matricariae Flos.Molecules (Basel, Switzerland) · 2023Article
- Rizatriptan-Loaded Oral Fast Dissolving Films: Design and Characterizations.Pharmaceutics · 2022Article
- Design and evaluation of sustained release mucoadhesive film of sumatriptan succinate containing grafted co-polymer as the platform.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022Article
- In Vitro Anticancer Activity of Mucoadhesive Oral Films Loaded withAntioxidants (Basel, Switzerland) · 2022Article
- Article
- Alginate/Chitosan-Based Hydrogel Film Containing α-Mangostin for Recurrent Aphthous Stomatitis Therapy in Rats.Pharmaceutics · 2022Article
- Investigation of Surface Properties and Free Volumes of Chitosan-Based Buccal Mucoadhesive Drug Delivery Films Containing Ascorbic Acid.Pharmaceutics · 2022Article
- Development and Optimization of Asenapine Sublingual Film Using QbD Approach.AAPS PharmSciTech · 2021Article
- D-Sorbitol Physical Properties Effects on Filaments Used by 3D Printing Process for Personalized Medicine.Molecules (Basel, Switzerland) · 2021Article
- Production of Reproducible Filament Batches for the Fabrication of 3D Printed Oral Forms.Pharmaceutics · 2021Article
- Mucoadhesive buccal film of almotriptan improved therapeutic delivery in rabbit model.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2020Article
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2 authors.
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Abstract
Mucoadhesive buccal film is developed as a promising dosage form, which has prominent advantages because of drug delivery through buccal mucosa. New formulation of buccal films containing rizatriptan benzoate (RB) was prepared by solvent casting method using various concentrations of hydroxypropyl methylcellulose (HPMC K4M), polyvinyl alcohol (PVA), polyethylene oxide (PEO), glycerol, stevia, and goat buccal mucosa used as a model membrane. In this work, the effect of polymers and plasticizer concentrations on drug release profile, disintegration and dissolution time, mechanical properties, and mucoadhesive characteristics of films was studied. Scanning electron microscopy analysis revealed uniform distribution of RB in film formulations. Chemical compounds and thermal analysis of the films were studied by Fourier transform infrared spectroscopy and differential scanning calorimetry, respectively. The buccal films produced were uniform in drug content and thickness. All formulations have in vitro release of 98-102% between 40 and 80 min. Also ex vivo mucoadhesion strength was in the range of 0.205 ± 0.035 to 0.790 ± 0.014 N for all formulations. A formulation consisting RB (50 mg), HPMC K4M, PVA, and PEO (63 mg), glycerol (1.5 ml), stevia (5 mg) was selected as our optimum composition. More satisfactory results were obtained in terms of disintegration and dissolution time, mechanical properties, and mucoadhesive characteristics. In addition, it showed about 99.89% RB released in 45 min. The results suggest that RB-loaded mucoadhesive buccal films could be a potential candidate to achieve optimum drug release for effective treatment of migraine.
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