Evidence map›Paper›PMID 29110140›Full record

ArticlePharmacoEconomics2017

Economic Evaluation of Implementing a Novel Pharmacogenomic Test (IDgenetix

Mehdi Najafzadeh, Jorge A Garces, Alejandra Maciel

Abstract readComparative Study
In one paragraph

Article in PharmacoEconomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Review
  7. Article
  8. Cost-effectiveness of pharmacogenomic-guided treatment for major depression.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2023
    Article
  9. Review
  10. Review
  11. A Pharmacogenomic-based Antidepressant Treatment for Patients with Major Depressive Disorder: Results from an 8-week, Randomized, Single-blinded Clinical Trial.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mehdi NajafzadehDivision of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Jorge A GarcesAltheaDx, 10578 Science Center Drive, San Diego, CA, 92121, USA.
Alejandra MacielAltheaDx, 10578 Science Center Drive, San Diego, CA, 92121, USA. AMaciel@altheadx.com.ORCID http://orcid.org/0000-0003-4456-2905

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe response to therapeutics varies widely in patients with depression and anxiety, making selection of an optimal treatment choice challenging. IDgenetix

objectiveThe objective of this study was to estimate the cost effectiveness of implementing a novel pharmacogenomic test (IDgenetix

methodsWe developed a discrete event simulation to compare clinical events, quality-adjusted life-years, and costs of the two treatment strategies. Target patients had a Hamilton Rating Scale for Depression Score ≥ 20 and/or a Hamilton Rating Scale for Anxiety score ≥ 18 at baseline. Remission, response, and no response were simulated based on the observed rates in the IDgenetix

resultsThe model predicted cumulative remission rates of 78 and 66% in IDgenetix

conclusionUsing the IDgenetix

Indexed as

AdolescentAdultAnxietyComputer SimulationCost-Benefit AnalysisCost SavingsDepressionFemaleHumansMaleMiddle AgedPharmacogeneticsPharmacogenomic TestingPsychiatric Status Rating ScalesQuality-Adjusted Life YearsRandomized Controlled Trials as Topic

Identifiers

PMID29110140
PMCPMC5684279

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.