Evidence map›Paper›PMID 29110070›Full record

ReviewSeminars in immunopathology2018

Dietary and metabolic modulators of hepatic immunity.

Antonella Carambia, Johannes Herkel

Abstract readReview
PubMed Publisher
In one paragraph

Review in Seminars in immunopathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. MAFLD and Celiac Disease in Children.International journal of molecular sciences · 2023
    Review
  4. Review
  5. The aryl hydrocarbon receptor in liver inflammation.Seminars in immunopathology · 2021
    Review
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Antonella CarambiaDepartment of Medicine I, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. a.carambia@uke.de.ORCID 0000-0002-6484-3424
Johannes HerkelDepartment of Medicine I, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. jherkel@uke.de.
Universität Hamburg · DE

Funding

Deutsche Forschungsgemeinschaft CA1691/2-1Deutsche Forschungsgemeinschaft SFB 841, KFO306
6 · The paper itself

Abstract

The liver is the central metabolic organ of the organism and is thus constantly exposed to gut-derived dietary and microbial antigens. The liver maintains homoeostatic tolerance to these mostly harmless antigens. However, the liver also functions as a barrier organ to harmful pathogens and is thus permissive to liver inflammation. The regulation of the delicate balance between liver tolerance and liver inflammation is of vital importance for the organism. In recent years, a general role for dietary components and metabolites as immune mediators has been emerging. However, although the liver is exposed to a great deal of metabolic mediators, surprisingly, little is known about their actual role in the regulation of hepatic immune responses. Here, we will explore the possible impacts of metabolic mediators for homoeostatic and pathological immunity in the liver, by highlighting selected examples of metabolic immune regulation in the liver.

Indexed as

DietAnimalsHomeostasisHumansLiverHepatic toleranceHepatitisInflammationLiver antigen-presenting cellsMetabolites

Identifiers

PMID29110070
OpenAlexW2767280866

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.