ArticleNanoscale2017
Carbon dots: promising biomaterials for bone-specific imaging and drug delivery.
Article in Nanoscale, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed.
- pH-responsive delivery of hydrophobic anticancer drugs using boron and nitrogen Co-doped carbon dots as fluorescent nanocarriers.Scientific reports · 2026Article
- Artemisia-derived carbon dots with excellent pharmacological activities and ROS scavenging for osteoarthritis treatment.Journal of nanobiotechnology · 2026Article
- Carbon dots-based drug delivery for bone regeneration.Frontiers in bioengineering and biotechnology · 2025Review
- Synthesis andHeliyon · 2024Article
- Quantum dots for bone tissue engineering.Materials today. Bio · 2024Review
- Colloidal Chiral Carbon Dots: An Emerging System for Chiroptical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Physicochemical and Inflammatory Analysis of Unconjugated and Conjugated Bone-Binding Carbon Dots.ACS omega · 2024Article
- Nanomaterial-assisted theranosis of bone diseases.Bioactive materials · 2023Review
- Investigation into Red Emission and Its Applications: Solvatochromic N-Doped Red Emissive Carbon Dots with Solvent Polarity Sensing and Solid-State Fluorescent Nanocomposite Thin Films.Molecules (Basel, Switzerland) · 2023Article
- Carbon Nanomaterial-Based Hydrogels as Scaffolds in Tissue Engineering: A Comprehensive Review.International journal of nanomedicine · 2023Review
- Recent progress of emitting long-wavelength carbon dots and their merits for visualization tracking, target delivery and theranostics.Theranostics · 2023Review
- Novel synthesis of fibronectin derived photoluminescent carbon dots for bioimaging applications.RSC advances · 2022Article
- Sensitive, Selective and Reliable Detection of FeMolecules (Basel, Switzerland) · 2022Article
- Intrinsic specificity of plain ammonium citrate carbon dots forMaterials today. Bio · 2022Article
- Recent advances in carbon quantum dots for virus detection, as well as inhibition and treatment of viral infection.Nano convergence · 2022Review
- Physicochemical Characterization and Antibacterial Properties of Carbon Dots from Two Mediterranean Olive Solid Waste Cultivars.Nanomaterials (Basel, Switzerland) · 2022Article
- Synthesis Mechanisms, Structural Models, and Photothermal Therapy Applications of Top-Down Carbon Dots from Carbon Powder, Graphite, Graphene, and Carbon Nanotubes.International journal of molecular sciences · 2022Article
- Fluorescent Carbon Dot-Supported Imaging-Based Biomedicine: A Comprehensive Review.Bioinorganic chemistry and applications · 2022Review
- In vivo characterization of carbon dots-bone interactions: toward the development of bone-specific nanocarriers for drug delivery.Drug delivery · 2021Article
- Turning waste into wealth: facile and green synthesis of carbon nanodots from pollutants and applications to bioimaging.Chemical science · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Bone-related diseases and dysfunctions are heavy burdens on our increasingly aged society. One important strategy to relieve this problem is through early detection and treatment of bone-related diseases. Towards this goal, there has been constant interest in developing novel bone-specific materials for imaging and drug delivery. Currently, however, materials that have high affinity and specificity towards bone are very limited. Carbon dots (C-dots) synthesized from carbon nanopowder bind to calcified bones in vivo with high affinity and specificity. In this study we show that bone binding is highly unique to a specific type of C-dot, and that this binding is non-toxic. Significantly, C-dots derived from other raw materials did not show any bone binding properties. These differences are attributed to the differences in surface chemistry of C-dot preparations, highlighting the heterogeneous nature of C-dots. Importantly, bone-binding by carbon nanopowder derived C-dots is not significantly altered by chemical functionalization of their surface. These unique properties indicate the potential applications of carbon nanopowder-derived C-dots as highly bone-specific bioimaging agents and drug carriers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.