ArticleTranslational vision science & technology2017
A Temporal White Noise Analysis for Extracting the Impulse Response Function of the Human Electroretinogram.
Article in Translational vision science & technology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Electroretinographic responses to periodic stimuli in primates and the relevance for visual perception and for clinical studies.Visual neuroscience · 2024Review
- Melanopsin-mediated amplification of cone signals in the human visual cortex.Proceedings. Biological sciences · 2024Article
- Stimulator compensation and generation of Gaussian noise stimuli with defined amplitude spectra for studying input-output relations of sensory systems.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2023Article
- Single opsin driven white noise ERGs in mice.Frontiers in neuroscience · 2023Article
- Luminance white noise electroretinograms (wnERGs) in mice.Frontiers in neuroscience · 2022Article
- Electroretinographic responses to luminance and cone-isolating white noise stimuli in macaques.Frontiers in neuroscience · 2022Article
- The influence of temporal frequency and stimulus size on the relative contribution of luminance and L-/M-cone opponent mechanisms in heterochromatic flicker ERGs.Documenta ophthalmologica. Advances in ophthalmology · 2021Article
- Melanopsin and Cone Photoreceptor Inputs to the Afferent Pupil Light Response.Frontiers in neurology · 2019Article
- Melanopsin photoreception contributes to human visual detection, temporal and colour processing.Scientific reports · 2018Article
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe introduce a method for determining the impulse response function (IRF) of the ERG derived from responses to temporal white noise (TWN) stimuli.
methodsThis white noise ERG (wnERG) was recorded in participants with normal trichromatic vision to full-field (Ganzfeld) and 39.3° diameter focal stimuli at mesopic and photopic mean luminances and at different TWN contrasts. The IRF was obtained by cross-correlating the TWN stimulus with the wnERG.
resultsWe show that wnERG recordings are highly repeatable, with good signal-to-noise ratio, and do not lead to blink artifacts. The wnERG resembles a flash ERG waveform with an initial negativity (N1) followed by a positivity (P1), with amplitudes that are linearly related to stimulus contrast. These N1 and N1-P1 components showed commonalties in implicit times with the a- and b-waves of flash ERGs. There was a clear transition from rod- to cone-driven wnERGs at ∼1 photopic cd.m
conclusionThe wnERG provides a new approach to study the physiology of the retina using a stimulation method with adaptation and contrast conditions similar to natural scenes to allow for independent variation of stimulus strength and mean luminance, which is not possible with the conventional flash ERG. TRANSLATIONAL RELEVANCE: The white noise ERG methodology will be of benefit for clinical studies and animal models in the evaluation of hypotheses related to cellular redundancy to understand the effects of disease on specific visual pathways.
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