ArticleFrontiers in immunology2017
SIgA, TGF-β1, IL-10, and TNFα in Colostrum Are Associated with Infant Group B
Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Human Milk Bioactive Compounds and Allergic- and Infectious-Related Infant Outcomes: A Systematic Review.Molecular nutrition & food research · 2026Pooled it
- Synergistic regulation of gut microbiota and metabolites by breast milk and probiotics in the prevention of neonatal necrotizing enterocolitis: mechanisms and prospects.Translational pediatrics · 2026Review
- Maternal provisions in type 1 diabetes: Evidence for both protective & pathogenic potential.Frontiers in immunology · 2023Review
- Article
- Bacterial and Host Determinants of Group B Streptococcal Infection of the Neonate and Infant.Frontiers in microbiology · 2022Review
- Review
- Maternal Carriage in Late-Onset Group B Streptococcus Disease, Italy.Emerging infectious diseases · 2021Article
- Understanding Factors in Group B Streptococcus Late-Onset Disease.Infection and drug resistance · 2021Review
- Associations of Breast Milk Microbiota, Immune Factors, and Fatty Acids in the Rat Mother-Offspring Pair.Nutrients · 2020Article
- Towards understanding global patterns of antimicrobial use and resistance in neonatal sepsis: insights from the NeoAMR network.Archives of disease in childhood · 2020Observational
- Maternal Immunization: Nature Meets Nurture.Frontiers in microbiology · 2020Review
- Perturbation of Thymocyte Development Underlies the PRRS Pandemic: A Testable Hypothesis.Frontiers in immunology · 2019Article
- Article
- Breast Milk Cytokines and Early Growth in Gambian Infants.Frontiers in pediatrics · 2018Article
- Neonatal intestinal colonization ofGut microbesArticle
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundGroup B
objectivesWe have investigated the association between SIgA and cytokines in breastmilk and infant GBS colonization and clearance.
methodsMother/infant GBS colonization was determined in a prospective cohort of 750 Gambian mother/infant pairs followed to day 89 of life. Anti-GBS secretory IgA bound to the surface of whole bacteria was assessed by flow cytometry and a panel of 12 cytokines quantified by mesoscale discovery in colostrum, breastmilk and serum.
resultsCompared with infants receiving low anti-GBS SIgA in colostrum, infants receiving high anti-GBS SIgA were at decreased risk of GBS colonization for serotypes III and V. Infants colonized at day 6 were twice as likely to receive colostrum with high TGF-β1, TNFα, IL10, and IL-6 compared to uncolonized infants. Infants receiving high colostral TGF-β1, TNFα, and IL-6 had two-fold enhanced GBS clearance between birth and day 89.
conclusionOur results suggest that the infant GBS colonization risk diminishes with increasing anti-GBS SIgA antibody in breastmilk and that key maternally derived cytokines might contribute to protection against infant colonization. These findings might be leveraged to develop interventions including maternal vaccination that may reduce infant GBS colonization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.