Evidence map›Paper›PMID 29109678›Full record

ArticleFrontiers in neural circuits2017

Identification of Genes that Maintain Behavioral and Structural Plasticity during Sleep Loss.

Laurent Seugnet, Stephane Dissel, Matthew Thimgan, Lijuan Cao, Paul J Shaw

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neural circuits, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. A conserved role forSleep advances : a journal of the Sleep Research Society · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. The neurobiological basis of sleep: Insights from Drosophila.Neuroscience and biobehavioral reviews · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Laurent SeugnetCentre de Recherche en Neurosciences de Lyon, U1028/UMR 5292, Team WAKING, Université Claude Bernard Lyon 1, INSERM U1028, CNRS UMR 5292, Lyon, France.
Stephane DisselDepartment of Neuroscience, Washington University School of Medicine, St. Louis, MO, United States.
Matthew ThimganDepartment of Biological Sciences, Missouri University of Science and Technology, Rolla, MO, United States.
Lijuan CaoDepartment of Neuroscience, Washington University School of Medicine, St. Louis, MO, United States.
Paul J ShawDepartment of Neuroscience, Washington University School of Medicine, St. Louis, MO, United States.
Washington University in St. Louis · USCentre de Recherche en Neurosciences de Lyon · FRMissouri University of Science and Technology · US

Funding

Washington University Center for Translational NeuroscienceP30NS057105 · NINDS · WASHINGTON UNIVERSITY · PI HOLTZMAN, DAVID M. · 2006 to 2011
$8.7M
FUNCTIONAL ANALYSIS OF SLEEP HOMEOSTASIS IN DROSOPHILAR01NS051305 · NINDS · WASHINGTON UNIVERSITY · PI SHAW, PAUL J · 2005 to 2023
$6.1M
Functional Analysis of Sleep Promoting Neurons in Health and DiseaseR01NS076980 · NINDS · WASHINGTON UNIVERSITY · PI SHAW, PAUL J · 2011 to 2020
$3.3M
Mechanisms Controlling Divergent Fates of Ovarian Follicles and FertilityR01HD076980 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI RICHARDS, JOANNE STEWART · 2014 to 2018
$1.9M
NICHD NIH HHS R01 HD076980NINDS NIH HHS P30 NS057105NINDS NIH HHS R01 NS051305NINDS NIH HHS R01 NS076980
6 · The paper itself

Abstract

Although patients with primary insomnia experience sleep disruption, they are able to maintain normal performance on a variety of cognitive tasks. This observation suggests that insomnia may be a condition where predisposing factors simultaneously increase the risk for insomnia and also mitigate against the deleterious consequences of waking. To gain insight into processes that might regulate sleep and buffer neuronal circuits during sleep loss, we manipulated three genes,

Indexed as

AnimalsAnimals, Genetically ModifiedDisease Models, AnimalDrosophilaDrosophila ProteinsEndopeptidasesHomeostasisLearningMemory, Short-TermMotor ActivityMushroom BodiesNerve Tissue ProteinsNeuronal PlasticityNeuronsReceptors, GABA-ASleep DeprivationDrosophila ProteinsEndopeptidasesHIW protein, DrosophilaNerve Tissue ProteinsRdl protein, DrosophilaReceptors, GABA-Aubiquitin-Nalpha-protein hydrolaseDrosophilaGABA-A receptorshomeostasislearningmemoryplasticitysleepubiquitin

Identifiers

PMID29109678
PMCPMC5660066
OpenAlexW2766742219

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.