ArticleScientific reports2017
NMR relaxation properties of the synthetic malaria pigment β-hematin.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 11 citations in OpenAlex.
- An ON-OFF Magneto-Optical Probe of Anisotropic Biofluid Crystals: AIEEE transactions on magnetics · 2021Article
- Diamond Magnetic Microscopy of Malarial Hemozoin Nanocrystals.Physical review applied · 2019Article
- Inorganic Complexes and Metal-Based Nanomaterials for Infectious Disease Diagnostics.Chemical reviews · 2019Review
- New Method of Production and Characterization of Haemozoin and B-Haemozoin fromIranian journal of parasitologyArticle
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Authors and funding
4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
200 million patients suffer from malaria, a parasitic disease caused by protozoans of the genus Plasmodium. Reliable diagnosis is crucial since it allows the early detection of the disease. The development of rapid, sensitive and low-cost diagnosis tools is an important research area. Different studies focused on the detection of hemozoin, a major by-product of hemoglobin detoxification by the parasite. Hemozoin and its synthetic analog, β-hematin, form paramagnetic crystals. A new detection method of malaria takes advantage of the paramagnetism of hemozoin through the effect that such magnetic crystals have on Nuclear Magnetic Resonance (NMR) relaxation of water protons. Indeed, magnetic microparticles cause a shortening of the relaxation times. In this work, the magnetic properties of two types of β-hematin are assessed at different temperatures and magnetic fields. The pure paramagnetism of β-hematin is confirmed. The NMR relaxation of β-hematin suspensions is also studied at different magnetic fields and for different echo-times. Our results help to identify the best conditions for β-hematin detection by NMR: T
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