Evidence map›Paper›PMID 29109537›Full record

ArticleScientific reports2017

Neuroprotective effect of Ruminococcus albus on oxidatively stressed SH-SY5Y cells and animals.

Jieun Park, Jiyun Lee, Zia Yeom, Donghyuk Heo, Young-Hee Lim

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Fermenting Acerola (Foods (Basel, Switzerland) · 2024
    Article
  6. Protective Effects of Heat-KilledJournal of microbiology and biotechnology · 2024
    Article
  7. Article
  8. Article
  9. Review
  10. Neuroprotective Effects of Heat-KilledJournal of microbiology and biotechnology · 2023
    Article
  11. Article
  12. Heat-KilledAntioxidants (Basel, Switzerland) · 2022
    Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Physicochemical Analysis of Yogurt Produced byFood science of animal resources · 2021
    Article
  19. Review
  20. Potential neuroprotective effects of heat-killedFood science and biotechnology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jieun ParkDepartment of Public Health Science (Brain Korea 21 PLUS program), Graduate School, Korea University, Seoul, 136-701, Republic of Korea.
Jiyun LeeDepartment of Public Health Science (Brain Korea 21 PLUS program), Graduate School, Korea University, Seoul, 136-701, Republic of Korea.
Zia YeomSchool of Biosystem and Biomedical Science, College of Health Science, Korea University, Seoul, 136-701, Republic of Korea.
Donghyuk HeoDepartment of Public Health Science (Brain Korea 21 PLUS program), Graduate School, Korea University, Seoul, 136-701, Republic of Korea.
Young-Hee LimDepartment of Public Health Science (Brain Korea 21 PLUS program), Graduate School, Korea University, Seoul, 136-701, Republic of Korea. yhlim@korea.ac.kr.
Korea University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent evidence shows that the gut microbiota has an important role in gut-brain crosstalk and is linked to neuronal disorders. The aim of this study was to investigate the effects of intestinal Ruminococcus albus with probiotic potential on neuroprotection in oxidatively stressed SH-SY5Y neuroblastoma cells and animals. To investigate these effects, conditioned medium was prepared using Caco-2 cells cultured with heat-killed R. albus (CRA-CM). Caco-2 cells cultured with heat-killed R. albus showed increased BDNF expression and BDNF protein levels increased in CRA-CM. CRA-CM up-regulated the protein expression levels of SRF, C-fos and CDK2. In addition, CRA-CM protected SH-SY5Y cells from H

Indexed as

RuminococcusAnimalsAntioxidantsApoptosisArsenatesBrain-Derived Neurotrophic FactorCell LineCell SurvivalDose-Response Relationship, DrugHot TemperatureHumansHydrogen PeroxideNeurogenesisNeuronsNeuroprotective AgentsOxidative StressAntioxidantsArsenatesBrain-Derived Neurotrophic FactorHydrogen PeroxideNeuroprotective AgentsReactive Oxygen Speciessodium arsenate

Identifiers

PMID29109537
PMCPMC5674049
OpenAlexW2765334410

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.