Evidence map›Paper›PMID 29109477›Full record

ArticleNature microbiology2018

Plasmodium UIS3 sequesters host LC3 to avoid elimination by autophagy in hepatocytes.

Eliana Real, Lénia Rodrigues, Ghislain G Cabal, Francisco J Enguita, Liliana Mancio-Silva, João Mello-Vieira, Wandy Beatty, Iset M Vera, Vanessa Zuzarte-Luís, Tiago N Figueira and 2 more

Abstract read
In one paragraph

Article in Nature microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 101 citations in OpenAlex.

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  14. Flp/Proceedings of the National Academy of Sciences of the United States of America · 2024
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 4 countries.

Eliana RealInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
Lénia RodriguesInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
Ghislain G CabalInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
Francisco J EnguitaInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.ORCID http://orcid.org/0000-0002-8072-8557
Liliana Mancio-SilvaInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
João Mello-VieiraInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
Wandy BeattyDepartment of Molecular Microbiology, Center for Infectious Disease Research, Washington University School of Medicine, St Louis, MO, USA.
Iset M VeraInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
Vanessa Zuzarte-LuísInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.ORCID http://orcid.org/0000-0003-0023-5953
Tiago N FigueiraInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.ORCID http://orcid.org/0000-0002-0813-0745
Gunnar R MairParasitology Department of Infectious Diseases, University of Heidelberg Medical School, Heidelberg, Germany.
Maria M MotaInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal. mmota@medicina.ulisboa.pt.ORCID http://orcid.org/0000-0002-2858-1041
University of Lisbon · PTHeidelberg University · DEWashington University in St. Louis · US

Funding

European Research Council 311502
6 · The paper itself

Abstract

The causative agent of malaria, Plasmodium, replicates inside a membrane-bound parasitophorous vacuole (PV), which shields this intracellular parasite from the cytosol of the host cell

Indexed as

AnimalsAutophagosomesAutophagyCell LineHEK293 CellsHepatocytesHep G2 CellsHost-Pathogen InteractionsHumansMalariaMaleMembrane ProteinsMiceMice, Inbred C57BLMicrotubule-Associated ProteinsModels, MolecularMap1lc3b protein, mouseMembrane ProteinsMicrotubule-Associated ProteinsProtozoan Proteins

Identifiers

PMID29109477
PMCPMC5739284
OpenAlexW2765815523

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.