Evidence map›Paper›PMID 29109450›Full record

ArticleScientific reports2017

Interactive phenotyping of large-scale histology imaging data with HistomicsML.

Michael Nalisnik, Mohamed Amgad, Sanghoon Lee, Sameer H Halani, Jose Enrique Velazquez Vega, Daniel J Brat, David A Gutman, Lee A D Cooper

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

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  11. Molecular Pathology of Lung Cancer.Cold Spring Harbor perspectives in medicine · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michael NalisnikDepartment of Biomedical Informatics, Emory University School of Medicine, Atlanta, USA.
Mohamed AmgadDepartment of Biomedical Informatics, Emory University School of Medicine, Atlanta, USA.
Sanghoon LeeDepartment of Neurology, Emory University School of Medicine, Atlanta, USA.
Sameer H HalaniEmory University School of Medicine, Atlanta, USA.
Jose Enrique Velazquez VegaDepartment of Pathology & Laboratory Medicine, Emory University School of Medicine, Atlanta, USA.
Daniel J BratDepartment of Pathology & Laboratory Medicine, Emory University School of Medicine, Atlanta, USA.
David A GutmanDepartment of Neurology, Emory University School of Medicine, Atlanta, USA.
Lee A D CooperDepartment of Biomedical Informatics, Emory University School of Medicine, Atlanta, USA. lee.cooper@emory.edu.ORCID 0000-0002-3504-4965

Funding

Advanced Development of an Open-source Platform for Web-based Integrative Digital Image Analysis in CancerU24CA194362 · NCI · EMORY UNIVERSITY · PI COOPER, LEE, GUTMAN, DAVID ANDREW · 2015 to 2019
$3.6M
Multiscale Framework for Molecular Heterogeneity AnalysisK22LM011576 · NLM · EMORY UNIVERSITY · PI COOPER, LEE · 2013 to 2015
$485k
NCI NIH HHS U24 CA194362NLM NIH HHS K22 LM011576
6 · The paper itself

Abstract

Whole-slide imaging of histologic sections captures tissue microenvironments and cytologic details in expansive high-resolution images. These images can be mined to extract quantitative features that describe tissues, yielding measurements for hundreds of millions of histologic objects. A central challenge in utilizing this data is enabling investigators to train and evaluate classification rules for identifying objects related to processes like angiogenesis or immune response. In this paper we describe HistomicsML, an interactive machine-learning system for digital pathology imaging datasets. This framework uses active learning to direct user feedback, making classifier training efficient and scalable in datasets containing 10

Indexed as

Histological TechniquesImage Interpretation, Computer-AssistedMachine LearningBiomarkers, TumorBrain NeoplasmsCohort StudiesEndothelial CellsGenetic Association StudiesGliomaHumansMicrovesselsPlatelet Endothelial Cell Adhesion Molecule-1PrognosisRNA, MessengerSoftwareBiomarkers, TumorPlatelet Endothelial Cell Adhesion Molecule-1RNA, Messenger

Identifiers

PMID29109450
PMCPMC5674015

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.