Evidence map›Paper›PMID 29109418›Full record

ArticleScientific reports2017

Extremely low frequency pulsed electromagnetic fields cause antioxidative defense mechanisms in human osteoblasts via induction of •O

Sabrina Ehnert, Anne-Kristin Fentz, Anna Schreiner, Johannes Birk, Benjamin Wilbrand, Patrick Ziegler, Marie K Reumann, Hongbo Wang, Karsten Falldorf, Andreas K Nussler

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
9.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 95 citations in OpenAlex.

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  10. Signalling pathways underlying pulsed electromagnetic fields in bone repair.Frontiers in bioengineering and biotechnology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Sabrina EhnertSiegfried Weller Institute for Trauma Research, Eberhard-Karls-Universität Tübingen, Schnarrenbergstr. 95, D-72076, Tübingen, Germany. sabrina.ehnert@med.uni-tuebingen.de.
Anne-Kristin FentzSachtleben GmbH, Hamburg, Spectrum UKE, Martinistraße 64, D-20251, Hamburg, Germany.
Anna SchreinerSiegfried Weller Institute for Trauma Research, Eberhard-Karls-Universität Tübingen, Schnarrenbergstr. 95, D-72076, Tübingen, Germany.
Johannes BirkSiegfried Weller Institute for Trauma Research, Eberhard-Karls-Universität Tübingen, Schnarrenbergstr. 95, D-72076, Tübingen, Germany.
Benjamin WilbrandSiegfried Weller Institute for Trauma Research, Eberhard-Karls-Universität Tübingen, Schnarrenbergstr. 95, D-72076, Tübingen, Germany.
Patrick ZieglerSiegfried Weller Institute for Trauma Research, Eberhard-Karls-Universität Tübingen, Schnarrenbergstr. 95, D-72076, Tübingen, Germany.
Marie K ReumannSiegfried Weller Institute for Trauma Research, Eberhard-Karls-Universität Tübingen, Schnarrenbergstr. 95, D-72076, Tübingen, Germany.
Hongbo WangWuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Dadao 1277#, 430022, Wuhan, China.
Karsten FalldorfSachtleben GmbH, Hamburg, Spectrum UKE, Martinistraße 64, D-20251, Hamburg, Germany.
Andreas K NusslerSiegfried Weller Institute for Trauma Research, Eberhard-Karls-Universität Tübingen, Schnarrenbergstr. 95, D-72076, Tübingen, Germany.
University of Tübingen · DEUniversity Medical Center Hamburg-Eppendorf · DEHuazhong University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, we identified a specific extremely low-frequency pulsed electromagnetic field (ELF-PEMF) that supports human osteoblast (hOBs) function in an ERK1/2-dependent manner, suggesting reactive oxygen species (ROS) being key regulators in this process. Thus, this study aimed at investigating how ELF-PEMF exposure can modulate hOBs function via ROS. Our results show that single exposure to ELF-PEMF induced ROS production in hOBs, without reducing intracellular glutathione. Repetitive exposure (>3) to ELF-PEMF however reduced ROS-levels, suggesting alterations in the cells antioxidative stress response. The main ROS induced by ELF-PEMF were •O

Indexed as

Electromagnetic FieldsAntioxidantsCatalaseGlutathione PeroxidaseHumansHydrogen PeroxideOsteoblastsReactive Oxygen SpeciesSuperoxide DismutaseSuperoxide Dismutase 2SuperoxidesAntioxidantsCatalaseGlutathione PeroxidaseGPX3 protein, humanHydrogen PeroxideReactive Oxygen SpeciesSuperoxide DismutaseSuperoxide Dismutase 2Superoxides

Identifiers

PMID29109418
PMCPMC5673962
OpenAlexW2766222258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.