ArticleScientific reports2017
Involvement of autophagy in the outcome of mitotic catastrophe.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Heat Stress from Calving to Mating: Mechanisms and Impact on Cattle Fertility.Animals : an open access journal from MDPI · 2025Review
- Review
- The Effect of Natural Substances Contained in Bee Products on Prostate Cancer in In Vitro Studies.Molecules (Basel, Switzerland) · 2023Article
- SIRT1 regulates mitotic catastrophe via autophagy and BubR1 signaling.Molecular and cellular biochemistry · 2022Article
- A novel ATG5 interaction with Ku70 potentiates DNA repair upon genotoxic stress.Scientific reports · 2022Article
- Impact of Heat Stress on Bovine Sperm Quality and Competence.Animals : an open access journal from MDPI · 2022Review
- Necroptosis as a Novel Facet of Mitotic Catastrophe.International journal of molecular sciences · 2022Article
- Autophagy and cancer treatment: four functional forms of autophagy and their therapeutic applications.Journal of Zhejiang University. Science. B · 2022Review
- A link between mitotic defects and mitotic catastrophe: detection and cell fate.Biology direct · 2021Review
- CHIR99021, trough GSK-3β Targeting, Reduces Epithelioid Sarcoma Cell Proliferation by Activating Mitotic Catastrophe and Autophagy.International journal of molecular sciences · 2021Article
- Advances in Intracellular Calcium Signaling Reveal Untapped Targets for Cancer Therapy.Biomedicines · 2021Review
- Boosting Replication and Penetration of Oncolytic Adenovirus by Paclitaxel Eradicate Peritoneal Metastasis of Gastric Cancer.Molecular therapy oncolytics · 2020Article
- Biology of Glioblastoma Multiforme-Exploration of Mitotic Catastrophe as a Potential Treatment Modality.International journal of molecular sciences · 2020Review
- ULK1-ATG13 and their mitotic phospho-regulation by CDK1 connect autophagy to cell cycle.PLoS biology · 2020Article
- Cell death through the ages: The ICDS 25th Anniversary Meeting.The FEBS journal · 2020Article
- An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis.Molecular cell · 2020Article
- Upregulation of Mcl-1S Causes Cell-Cycle Perturbations and DNA Damage Accumulation.Frontiers in cell and developmental biology · 2020Article
- The DNA-damage response and nuclear events as regulators of nonapoptotic forms of cell death.Oncogene · 2020Review
- Quantitative assessment of changes in cellular morphology at photodynamic treatmentBiomedical optics express · 2019Article
- Morphological changes in the ovarian carcinoma cells of Wistar rats induced by chemotherapy with cisplatin and dioxadet.Biomedical optics express · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evading cell death is a major driving force for tumor progression that is one of the main problems in current cancer research. Mitotic catastrophe (MC) represents attractive platform compromising tumor resistance to current therapeutic modalities. MC appeared as onco-suppressive mechanism and is defined as a stage driving the cell to an irreversible destiny, i.e. cell death via apoptosis or necrosis. Our study highlights that MC induction in colorectal carcinoma cell lines ultimately leads to the autophagy followed by apoptosis. We show that autophagy suppression in Atg 13 knockout non-small cell lung carcinoma cells lead to the dramatic decrease of MC rate. Furthermore, mitochondria-linked anti-apoptotic proteins Mcl-1 and Bcl-xL play a crucial role in the duration of MC and a cross-talk between autophagy and apoptosis. Thus, the suppression of apoptosis by overexpression of Mcl-1 or Bcl-xL affected MC and lead to a significant induction of autophagy in HCT116 wt and HCT116 14-3-3σ
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.