ArticleScientific reports2017
Mutation accumulation under UV radiation in Escherichia coli.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Accelerated Adaptive Evolution of Gram-Negative Bacteria With a Broad-Host-Range Dual Base Editor.Microbial biotechnology · 2026Article
- Pyocyanin produced byAntimicrobial agents and chemotherapy · 2026Article
- UV-B-induced DNA repair mechanisms and their effects on mutagenesis and culturability inmSystems · 2026Article
- Extended sequence context shapes mutational bias inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- UV-C LED wavelength effects on inactivation kinetics, DNA damage and membrane integrity in drinking water indicator bacteria.Scientific reports · 2026Article
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- Enhanced glutathione production by a non-GMOFood science and biotechnology · 2025Article
- Genome-wide strand-specific UV mutagenesis inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Loss of Heterozygosity associated with ubiquitous environments in yeast.PLoS genetics · 2025Article
- Quantitative analysis of relationship between mutation rate and speed of adaptation under antibiotic exposure in Escherichia coli.PLoS genetics · 2025Article
- Nanopore- and AI-empowered microbial viability inference.GigaScience · 2025Article
- Investigation on possible resistance ofmicroPublication biology · 2025Article
- Development of specialized devices for microbial experimental evolution.Development, growth & differentiation · 2024Review
- Exploring the links between SOS response, mutagenesis, and resistance during the recovery period.Antimicrobial agents and chemotherapy · 2024Article
- A Comprehensive Assessment of Ultraviolet-Radiation-Induced Mutations inJournal of fungi (Basel, Switzerland) · 2024Article
- Impact of the chemical modification of tRNAs anticodon loop on the variability and evolution of codon usage in proteobacteria.Frontiers in microbiology · 2024Article
- The use of droplet-based microfluidic technologies for accelerated selection ofBiology methods & protocols · 2024Review
- Competition and evolutionary selection among core regulatory motifs in gene expression control.Nature communications · 2023Article
- Model selection and robust inference of mutational signatures using Negative Binomial non-negative matrix factorization.BMC bioinformatics · 2023Article
- Abiotic selection of microbial genome size in the global ocean.Nature communications · 2023Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Mutations are induced by not only intrinsic factors such as inherent molecular errors but also by extrinsic mutagenic factors such as UV radiation. Therefore, identifying the mutational properties for both factors is necessary to achieve a comprehensive understanding of evolutionary processes both in nature and in artificial situations. Although there have been extensive studies on intrinsic factors, the mutational profiles of extrinsic factors are poorly understood on a genomic scale. Here, we explored the mutation profiles of UV radiation, a ubiquitous mutagen, in Escherichia coli on the genomic scale. We performed an evolution experiment under periodic UV radiation for 28 days. The accumulation speed of the mutations was found to increase so that it exceeded that of a typical mutator strain with deficient mismatch repair processes. The huge contribution of the extrinsic factors to all mutations consequently increased the risk of the destruction of inherent error correction systems. The spectrum of the UV-induced mutations was broader than that of the spontaneous mutations in the mutator. The broad spectrum and high upper limit of the frequency of occurrence suggested ubiquitous roles for UV radiation in accelerating the evolutionary process.
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