Evidence map›Paper›PMID 29109289›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Host-based lipid inflammation drives pathogenesis in

Alison J Scott, Julia Maria Post, Raissa Lerner, Shane R Ellis, Joshua Lieberman, Kari Ann Shirey, Ron M A Heeren, Laura Bindila, Robert K Ernst

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. bioRxiv : the preprint server for biology · 2023
    Article
  8. ReducingAnalytical chemistry · 2023
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Alison J ScottDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, MD 21201.ORCID 0000-0001-6969-4707
Julia Maria PostLaboratory for Eicosanoids and Endocannabinoids, Johannes Gutenberg University Mainz, 55099 Mainz, Germany.
Raissa LernerLaboratory for Eicosanoids and Endocannabinoids, Johannes Gutenberg University Mainz, 55099 Mainz, Germany.
Shane R EllisMaastricht MultiModal Molecular Imaging Institute, Maastricht University, 6229 ER Maastricht, The Netherlands.
Joshua LiebermanDepartment of Pathology, University of Washington Medical Center, Seattle, WA 98118.
Kari Ann ShireyDepartment of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, MD 21201.
Ron M A HeerenMaastricht MultiModal Molecular Imaging Institute, Maastricht University, 6229 ER Maastricht, The Netherlands.ORCID 0000-0002-6533-7179
Laura BindilaLaboratory for Eicosanoids and Endocannabinoids, Johannes Gutenberg University Mainz, 55099 Mainz, Germany.
Robert K ErnstDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, MD 21201; rkernst@umaryland.edu.ORCID 0000-0001-5016-8694
Johannes Gutenberg University Mainz · DEUniversity of Maryland, Baltimore · USMaastricht University · NLUniversity of Washington Medical Center · US

Funding

Signaling Pathways in Innate ImmunityT32AI095190 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Stefanie N. Vogel · 2012 to 2026
$4.7M
IMMUNITY AND INFECTIONT32AI007540 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI KAPER, JAMES B · 1998 to 2018
$2.2M
Protection Against Gram-Negative Sepsis Conferred by Lipid A-Based Structural VariantsR01AI123820 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI ERNST, ROBERT K, GOODLETT, DAVID ROBINSON · 2016 to 2019
$1.5M
MS diagnostic bacterial identification libraryR01GM111066 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI ERNST, ROBERT K, GOODLETT, DAVID ROBINSON · 2014 to 2017
$1.2M
NIAID NIH HHS R01 AI123820NIAID NIH HHS T32 AI007540NIAID NIH HHS T32 AI095190NIGMS NIH HHS R01 GM111066
6 · The paper itself

Abstract

Mass spectrometry imaging (MSI) was used to elucidate host lipids involved in the inflammatory signaling pathway generated at the host-pathogen interface during a septic bacterial infection. Using

Indexed as

Host-Pathogen InteractionsAnimalsCyclooxygenase 2DinoprostoneEicosanoidsEndotoxinsFemaleFrancisellaGene ExpressionGram-Negative Bacterial InfectionsImmunity, InnateInflammationMacrophagesMass SpectrometryMiceMice, Inbred C57BLCyclooxygenase 2DinoprostoneEicosanoidsEndotoxinsPhospholipidsPtgs2 protein, mousecyclooxygenase pathwayhost–pathogen interactionlipid inflammationmass spectrometry imagingmicrobial pathogenesis

Identifiers

PMID29109289
PMCPMC5703311
OpenAlexW2767793175

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.