ArticleProceedings of the National Academy of Sciences of the United States of America2017
Circadian clock cryptochrome proteins regulate autoimmunity.
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 60 papers.
0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 100 citations in OpenAlex.
- Trial
- Circadian synchronization between diet and gut microbiota in modulating host's health.Gut microbes · 2026Review
- Cryptochrome Loss Drives COPD-like Lung Pathology through Disrupted Alveolar Epithelial Proliferation and Immune Homeostasis.bioRxiv : the preprint server for biology · 2026Article
- Targeting Cryptochromes in Chronic Diseases.Cell biology international · 2025Review
- Transcriptomic analysis reveals the immunomodulatory role ofAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Circadian Clock: A Regulator of Immunity in Autoimmune Diseases.Immunity, inflammation and disease · 2025Review
- Relationship Between Sleep and Immunology in Attention Deficit Hyperactivity Disorder.International journal of molecular sciences · 2025Review
- The βScience advances · 2025Article
- Identifying causal genes for prostatitis through drug-targeted Mendelian randomization.Scientific reports · 2025Article
- Chronic CRYPTOCHROME deficiency enhances cell-intrinsic antiviral defences.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Development of compounds for targeted degradation of mammalian cryptochrome proteins.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Unveiling the novel role of circadian rhythms in sepsis and septic shock: unexplored implications for chronotherapy.Frontiers in endocrinology · 2025Review
- Challenges and opportunities for statistical power and biomarker identification arising from rhythmic variation in proteomics.Npj biological timing and sleep · 2025Article
- Circadian clocks and adaptive immune function: from mechanisms to therapeutic applications.Frontiers in immunology · 2025Review
- Complement Immune System in Pulmonary Hypertension-Cooperating Roles of Circadian Rhythmicity in Complement-Mediated Vascular Pathology.International journal of molecular sciences · 2024Review
- Circadian rhythm disruption and endocrine-related tumors.World journal of clinical oncology · 2024Review
- Circadian rhythms in solid organ transplantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2024Review
- Exacerbating effects of circadian rhythm disruption on the systemic lupus erythematosus.Lupus science & medicine · 2024Article
- Review
- Circadian immunity from bench to bedside: a practical guide.The Journal of clinical investigation · 2024Review
Corrections and comments
- Erratum issued
Authors and funding
26 authors at 10 institutions in 4 countries.
Qi CaoDepartment of Hematology and Oncology, Cedars-Sinai Medical Center, Los Angeles, CA 90048; caodapi@gmail.com downes@salk.edu evans@salk.edu.
Xuan ZhaoGene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037.
Jingwen BaiDepartment of Hematology and Oncology, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
Sigal GeryDepartment of Hematology and Oncology, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
Haibo SunDepartment of Hematology and Oncology, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
De-Chen LinDepartment of Hematology and Oncology, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
Qi ChenDepartment of Endocrinology, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
Zhengshan ChenDepartment of Pathology and Laboratory Medicine, LAC+USC Medical Center, Los Angeles, CA 90033.
Lauren MackNomis Foundation Laboratories for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, La Jolla, CA 92037.
Henry YangCancer Science Institute of Singapore, National University of Singapore, Singapore 117599.
Ruishu DengSanford Burnham Preybs Medical Discovery Institute, La Jolla, CA 92037.
Xianping ShiDepartment of Hematology and Oncology, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
Ling-Wa ChongGene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037.
Han ChoGene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037.
Jianjun XieDepartment of Hematology and Oncology, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
Quan-Zhen LiDepartment of Immunology, Microarray Core Facility, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Markus MüschenDepartment of Systems Biology, Beckman Research Institute, City of Hope National Medical Center, Pasadena, CA 91016.
Annette R AtkinsGene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037.
Christopher LiddleStorr Liver Centre, Westmead Institute for Medical Research and Sydney Medical School, University of Sydney, Westmead Hospital, Westmead, NSW 2145, Australia.
Ruth T YuGene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037.
Serhan AlkanDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
Jonathan W SaidDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles Medical Center, Los Angeles, CA 90095.
Ye ZhengNomis Foundation Laboratories for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, La Jolla, CA 92037.
Michael DownesGene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037; caodapi@gmail.com downes@salk.edu evans@salk.edu.
Ronald M EvansGene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037; caodapi@gmail.com downes@salk.edu evans@salk.edu.
H Phillip KoefflerDepartment of Hematology and Oncology, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
Salk Institute for Biological Studies · USCedars-Sinai Medical Center · USLAC+USC Medical Center · USNational University Cancer Institute, Singapore · SGCity Of Hope National Medical Center · USDiscovery Institute · USFirst Affiliated Hospital of Xiamen University · CNLos Angeles Medical Center · USThe University of Texas Southwestern Medical Center · USWestmead Institute for Medical Research · AU
Funding
Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Reuben Shaw · 1985 to 2026
$82.8MYeast Genetics and Stress Response Genes-BiomedicalP42ES010337 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2000 to 2022
$69.8MTranscriptional GenomicsP01HL088093 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WITZTUM, JOSEPH L. · 2008 to 2018
$26.4MHORMONAL REGULATION OF MAMMALIAN GENE EXPRESSIONR37DK057978 · NIDDK · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EVANS, RONALD M · 2000 to 2019
$16.0MMetabolic gatekeepers in B-cell malignanciesR35CA197628 · NCI · YALE UNIVERSITY · PI Markus Müschen · 2016 to 2026
$11.7MTreg development and function controlled by cis-regulatory circuitsR01AI107027 · NIAID · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI ZHENG, YE · 2014 to 2022
$5.0MSpatial Regulation of Developmental Gene ExpressionR01HL105278 · NHLBI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EVANS, RONALD M · 2011 to 2019
$4.0MHormonal Regulation of Mammalian Gene ExpressionR01DK057978 · NIDDK · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EVANS, RONALD M · 2021 to 2024
$2.6MCD25-mediated feedback control of BCR-signaling and its oncogenic mimicsR01CA213138 · NCI · YALE UNIVERSITY · PI MÜSCHEN, MARKUS · 2017 to 2022
$1.9MHoward Hughes Medical InstituteNCI NIH HHS P30 CA014195NHLBI NIH HHS P01 HL088093NHLBI NIH HHS R01 HL105278NIDDK NIH HHS R01 DK057978NIDDK NIH HHS R37 DK057978NIEHS NIH HHS P42 ES010337
Abstract
The circadian system regulates numerous physiological processes including immune responses. Here, we show that mice deficient of the circadian clock genes
Indexed as
AnimalsAntibodies, AntinuclearAutoimmune DiseasesAutoimmunityB-LymphocytesCircadian ClocksComplement C1qCryptochromesGene Expression ProfilingGene Expression RegulationKidneyLungLymphocyte ActivationMaleMiceMice, Inbred C57BLAntibodies, AntinuclearComplement C1qCry1 protein, mouseCry2 protein, mouseCryptochromesReceptors, Antigen, B-CellautoimmuneB cell receptorcryptochrome
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.