ArticleProceedings of the National Academy of Sciences of the United States of America2017
SIRPα
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Direct Tumor Suppression by Anti-Basigin Antibody and Enhancement of Macrophage-Mediated Cancer Cell Phagocytosis under SIRPα Blockade.The Kobe journal of medical sciences · 2026Article
- Enhancing H11 Protein-Induced Immune Protection AgainstBiology · 2025Article
- Review
- Deciphering the role of CD47 in cancer immunotherapy.Journal of advanced research · 2024Review
- Distinct fibroblast functions associated with fibrotic and immune-mediated inflammatory diseases and their implications for therapeutic development.F1000Research · 2024Review
- Aging of lymphoid stromal architecture impacts immune responses.Seminars in immunology · 2023Review
- THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer.Nature communications · 2023Article
- CD47 promotes peripheral T cell survival by preventing dendritic cell-mediated T cell necroptosis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Activation of regulatory dendritic cells by Mertk coincides with a temporal wave of apoptosis in neonatal lungs.Science immunology · 2023Article
- Targeting of SIRPα as a potential therapy for Langerhans cell histiocytosis.Cancer science · 2023Article
- Lymph node fibroblastic reticular cells preserve a tolerogenic niche in allograft transplantation through laminin α4.The Journal of clinical investigation · 2022Article
- Review
- Chemo- and mechanosensing by dendritic cells facilitate antigen surveillance in the spleen.Immunological reviews · 2022Review
- SIRPα - CD47 axis regulates dendritic cell-T cell interactions and TCR activation during T cell priming in spleen.PloS one · 2022Article
- Compartmentalized multicellular crosstalk in lymph nodes coordinates the generation of potent cellular and humoral immune responses.European journal of immunology · 2021Review
- Low-dose 2-deoxy glucose stabilises tolerogenic dendritic cells and generates potent in vivo immunosuppressive effects.Cellular and molecular life sciences : CMLS · 2021Article
- Inflammation Unrestrained by SIRPα Induces Secondary Hemophagocytic Lymphohistiocytosis Independent of IFN-γ.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- CD47 as a Potential Target to Therapy for Infectious Diseases.Antibodies (Basel, Switzerland) · 2020Review
- Lymph node stromal cells: cartographers of the immune system.Nature immunology · 2020Review
- Perivascular Adventitial Fibroblast Specialization Accompanies T Cell Retention in the Inflamed Human Dermis.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In secondary lymphoid organs, development and homeostasis of stromal cells such as podoplanin (Pdpn)-positive fibroblastic reticular cells (FRCs) are regulated by hematopoietic cells, but the cellular and molecular mechanisms of such regulation have remained unclear. Here we show that ablation of either signal regulatory protein α (SIRPα), an Ig superfamily protein, or its ligand CD47 in conventional dendritic cells (cDCs) markedly reduced the number of CD4
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.