ArticleProceedings of the National Academy of Sciences of the United States of America2017
M-current inhibition rapidly induces a unique CK2-dependent plasticity of the axon initial segment.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 69 citations in OpenAlex.
- Abl kinase activation promotes axon initial segment disassembly and protein sorting defects in Alzheimer's disease.BMC biology · 2026Article
- Coupling of functionality to trafficking of KCNQ2/3 potassium channels at the axon initial segment.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Impaired AIS plasticity in ankyrin-G mutant mice alters cortical excitability and behavior.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Cryptic splicing in synaptic and membrane excitability genes links TDP-43 loss to neuronal dysfunction.bioRxiv : the preprint server for biology · 2025Article
- Axon initial segment structure and function in health and disease.Physiological reviews · 2025Review
- Long-term muscarinic inhibition increases intrinsic excitability through the upregulation of A-type potassium currents in cortical neurons.Frontiers in cell and developmental biology · 2025Article
- Beyond a Transmission Cable-New Technologies to Reveal the Richness in Axonal Electrophysiology.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Cholinergic stimulation stabilizes TRPM4 in the plasma membrane of cortical pyramidal neurons.Frontiers in cell and developmental biology · 2024Article
- Casein Kinase 2 Affects Epilepsy by Regulating Ion Channels: A Potential Mechanism.CNS & neurological disorders drug targets · 2024Review
- Measuring Action Potential Propagation Velocity in Murine Cortical Axons.Bio-protocol · 2023Article
- Cholinergic Stimulation Modulates the Functional Composition of CA3 Cell Types in the Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- SUMOylation of NaeLife · 2023Article
- Homeostatic plasticity of axonal excitable sites in Alzheimer's disease.Frontiers in neuroscience · 2023Article
- Contextual fear response is modulated by M-type K+ channels and is associated with subtle structural changes of the axon initial segment in hippocampal GABAergic neurons.AIMS neuroscience · 2023Article
- Structural plasticity of the axon initial segment in rat hippocampal granule cells following high frequency stimulation and LTP induction.Frontiers in neuroanatomy · 2023Article
- Article
- Tracking axon initial segment plasticity using high-density microelectrode arrays: A computational study.Frontiers in neuroinformatics · 2022Article
- Poly-dipeptides produced fromProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Excitatory and inhibitory hippocampal neurons differ in their homeostatic adaptation to chronic M-channel modulation.Frontiers in molecular neuroscience · 2022Article
- Ultrafast population coding and axo-somatic compartmentalization.PLoS computational biology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alterations in synaptic input, persisting for hours to days, elicit homeostatic plastic changes in the axon initial segment (AIS), which is pivotal for spike generation. Here, in hippocampal pyramidal neurons of both primary cultures and slices, we triggered a unique form of AIS plasticity by selectively targeting M-type K
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.