Evidence map›Paper›PMID 29109235›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

Glial Draper Rescues Aβ Toxicity in a

Arpita Ray, Sean D Speese, Mary A Logan

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
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  10. Glial Regulation of Circuit Wiring, Firing, and Expiring in theCold Spring Harbor perspectives in biology · 2024
    Review
  11. Review
  12. Article
  13. Impairment of the Glial Phagolysosomal System Drives Prion-Like Propagation in aThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Arpita RayJungers Center for Neurosciences Research, Department of Neurology, Oregon Health and Science University (OHSU), Portland, Oregon 97239.
Sean D SpeeseJungers Center for Neurosciences Research, Department of Neurology, Oregon Health and Science University (OHSU), Portland, Oregon 97239.
Mary A LoganJungers Center for Neurosciences Research, Department of Neurology, Oregon Health and Science University (OHSU), Portland, Oregon 97239 loganm@ohsu.edu.
Center for Neurosciences · USOregon Health & Science University · US

Funding

Role of Insulin-like Signaling in Glial Responses to Axon DegenerationR01NS079387 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI LOGAN, MARY ALLISON · 2012 to 2016
$1.6M
Investigating the Role of Draper/MEGF10 in Alzheimer's DiseaseR21AG056747 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI LOGAN, MARY ALLISON · 2017 to 2018
$424k
Transcriptome analysis of glia responding to injuryR21NS084112 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI LOGAN, MARY ALLISON, SPEESE, SEAN DAVID · 2013 to 2014
$422k
NIA NIH HHS R21 AG056747NINDS NIH HHS R01 NS079387NINDS NIH HHS R21 NS084112
6 · The paper itself

Abstract

Pathological hallmarks of Alzheimer's disease (AD) include amyloid-β (Aβ) plaques, neurofibrillary tangles, and reactive gliosis. Glial cells offer protection against AD by engulfing extracellular Aβ peptides, but the repertoire of molecules required for glial recognition and destruction of Aβ are still unclear. Here, we show that the highly conserved glial engulfment receptor Draper/MEGF10 provides neuroprotection in an AD model of

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsAnimals, Genetically ModifiedDrosophilaDrosophila ProteinsFemaleMaleMembrane ProteinsMiceNeurogliaPeptide FragmentsAmyloid beta-Peptidesamyloid beta-protein (1-42)Drosophila Proteinsdrpr protein, DrosophilaMembrane ProteinsPeptide FragmentsamyloidautophagyDraperDrosophilaglia

Identifiers

PMID29109235
PMCPMC5719972
OpenAlexW2767473351

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.