Evidence map›Paper›PMID 29109157›Full record

ArticleRNA (New York, N.Y.)2018

An ultraprocessive, accurate reverse transcriptase encoded by a metazoan group II intron.

Chen Zhao, Fei Liu, Anna Marie Pyle

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 95 citations in OpenAlex.

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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Chen ZhaoDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA.
Fei LiuDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA.
Anna Marie PyleDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA.
Howard Hughes Medical Institute · USYale University · US

Funding

STUCTURE AND FUNCTION OF GROUP II INTRONSR01GM050313 · NIGMS · YALE UNIVERSITY · PI PYLE, ANNA MARIE · 1994 to 2016
$4.6M
Monitoring Variation in Mixtures of Long RNAs with End-to-End RT SequencingR01HG009622 · NHGRI · YALE UNIVERSITY · PI GRAVELEY, BRENTON R., PYLE, ANNA MARIE · 2017 to 2019
$3.2M
Howard Hughes Medical InstituteNHGRI NIH HHS R01 HG009622NIGMS NIH HHS R01 GM050313
6 · The paper itself

Abstract

Group II introns and non-LTR retrotransposons encode a phylogenetically related family of highly processive reverse transcriptases (RTs) that are essential for mobility and persistence of these retroelements. Recent crystallographic studies on members of this RT family have revealed that they are structurally distinct from the retroviral RTs that are typically used in biotechnology. However, quantitative, structure-guided analysis of processivity, efficiency, and accuracy of this alternate RT family has been lacking. Here, we characterize the processivity of a group II intron maturase RT from

Indexed as

IntronsDNA, ComplementaryEubacteriumGenome, ViralHepacivirusRNA-Directed DNA PolymeraseDNA, ComplementaryRNA-Directed DNA Polymerasegroup II intronintron-encoded proteinmaturaseprocessivityreverse transcriptaseRNA-seq

Identifiers

PMID29109157
PMCPMC5769746
OpenAlexW2767788891

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.