Evidence map›Paper›PMID 29109154›Full record

ArticleThe EMBO journal2017

Hierarchical protein targeting and secretion is controlled by an affinity switch in the type III secretion system of enteropathogenic

Athina G Portaliou, Konstantinos C Tsolis, Maria S Loos, Vassileia Balabanidou, Josep Rayo, Alexandra Tsirigotaki, Valerie F Crepin, Gad Frankel, Charalampos G Kalodimos, Spyridoula Karamanou and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in The EMBO journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 67 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. FlaG competes with FliS-flagellin complexes for access to FlhA in the flagellar T3SS to controlProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Article
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  11. BopN is a Gatekeeper of theMicrobiology spectrum · 2023
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Cryoelectron-microscopy structure of the enteropathogenicProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 4 countries.

Athina G PortaliouLaboratory of Molecular Bacteriology, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Konstantinos C TsolisLaboratory of Molecular Bacteriology, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Maria S LoosLaboratory of Molecular Bacteriology, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Vassileia BalabanidouInstitute of Molecular Biology and Biotechnology, FORTH (Foundation of Research and Technology), University of Crete, Heraklion, Greece.
Josep RayoLaboratory of Molecular Bacteriology, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Alexandra TsirigotakiLaboratory of Molecular Bacteriology, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Valerie F CrepinDepartment of Life Sciences, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, UK.ORCID 0000-0002-9681-8418
Gad FrankelDepartment of Life Sciences, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, UK.
Charalampos G KalodimosUniversity of Minnesota Biochemistry, Molecular Biology & Biophysics, Minneapolis, MN, USA.
Spyridoula KaramanouLaboratory of Molecular Bacteriology, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium lily.karamanou@kuleuven.be tassos.economou@kuleuven.be.ORCID 0000-0002-8803-1404
Anastassios EconomouLaboratory of Molecular Bacteriology, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium lily.karamanou@kuleuven.be tassos.economou@kuleuven.be.ORCID 0000-0002-1770-507X
Rega Institute for Medical Research · BEImperial College London · GBUniversity of Crete · GRUniversity of Minnesota · US

Funding

Structural insight into novel mechanisms of type III secretionR01AI094623 · NIAID · UNIVERSITY OF MINNESOTA · PI KALODIMOS, CHARALAMPOS · 2012 to 2023
$4.0M
Structural insight into novel mechanisms of type III secretionR56AI094623 · NIAID · RUTGERS, THE STATE UNIV OF N.J. · PI KALODIMOS, CHARALAMPOS · 2011 to 2011
$366k
Medical Research Council MR/P028225/1NIAID NIH HHS R01 AI094623NIAID NIH HHS R56 AI094623Wellcome Trust
6 · The paper itself

Abstract

Type III secretion (T3S), a protein export pathway common to Gram-negative pathogens, comprises a trans-envelope syringe, the injectisome, with a cytoplasm-facing translocase channel. Exported substrates are chaperone-delivered to the translocase, EscV in enteropathogenic

Indexed as

Cell MembraneEnteropathogenic Escherichia coliEscherichia coli ProteinsModels, BiologicalModels, MolecularMolecular ChaperonesProtein ConformationProtein Interaction Domains and MotifsProtein TransportType III Secretion SystemsCesa protein, E coliEscherichia coli ProteinsEspA protein, E coliMolecular ChaperonesSepL protein, E coliType III Secretion SystemschaperoneEPECin vitro reconstitutionsubstrate switchingtype III secretion

Identifiers

PMID29109154
PMCPMC5709732
OpenAlexW2767492428

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.