Evidence map›Paper›PMID 29109151›Full record

ArticleThe Journal of biological chemistry2017

Peropsin modulates transit of vitamin A from retina to retinal pigment epithelium.

Jeremy D Cook, Sze Yin Ng, Marcia Lloyd, Shannan Eddington, Hui Sun, Jeremy Nathans, Dean Bok, Roxana A Radu, Gabriel H Travis

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. iScience · 2020
    Article
  11. Single particle cryo-EM of the complex between interphotoreceptor retinoid-binding protein and a monoclonal antibody.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  12. Article
  13. Review
  14. Photic generation of 11-The Journal of biological chemistry · 2019
    Article
  15. Structural biology of 11-The Biochemical journal · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Jeremy D CookFrom the Department of Ophthalmology, Stein Eye Institute.
Sze Yin NgFrom the Department of Ophthalmology, Stein Eye Institute.
Marcia LloydFrom the Department of Ophthalmology, Stein Eye Institute.
Shannan EddingtonFrom the Department of Ophthalmology, Stein Eye Institute.
Hui SunFrom the Department of Ophthalmology, Stein Eye Institute.
Jeremy NathansDepartment of Molecular Biology and Genetics, Neuroscience, and Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, and.
Dean BokFrom the Department of Ophthalmology, Stein Eye Institute.
Roxana A RaduFrom the Department of Ophthalmology, Stein Eye Institute.
Gabriel H TravisFrom the Department of Ophthalmology, Stein Eye Institute, travis@jsei.ucla.edu.
Czech Academy of Sciences, Institute of Physiology · CZJohns Hopkins Medicine · USUniversity of California, Los Angeles · US

Funding

Vision Research Core at UCLAP30EY000331 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Gregory Darin Field, DAVID S WILLIAMS · 1985 to 2026
$16.8M
The Role of Muller Cells in Visual Pigment RegenerationR01EY011713 · NEI · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI TRAVIS, GABRIEL H · 1997 to 2017
$6.9M
Mechanisms for Light-driven Chromophore Synthesis by Müller Cells to Regenerate Cone Opsin and Maintain Cone SensitivityR01EY024379 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TRAVIS, GABRIEL H · 2015 to 2024
$3.3M
The Role of Complement in Recessive Stargardt DiseaseR01EY025002 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RADU, ROXANA A · 2015 to 2019
$1.9M
HIGH-END CRYOEM INSTRUMENT FOR UCLA ELECTRON IMAGING CTR FOR NANOMACHINES: AIDSS10RR023057 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHOU, Z HONG · 2006 to 2006
$1.6M
Howard Hughes Medical InstituteNCRR NIH HHS S10 RR023057NEI NIH HHS P30 EY000331NEI NIH HHS R01 EY011713NEI NIH HHS R01 EY024379NEI NIH HHS R01 EY025002
6 · The paper itself

Abstract

Peropsin is a non-visual opsin in both vertebrate and invertebrate species. In mammals, peropsin is present in the apical microvilli of retinal pigment epithelial (RPE) cells. These structures interdigitate with the outer segments of rod and cone photoreceptor cells. RPE cells play critical roles in the maintenance of photoreceptors, including the recycling of visual chromophore for the opsin visual pigments. Here, we sought to identify the function of peropsin in the mouse eye. To this end, we generated mice with a null mutation in the peropsin gene (

Indexed as

AnimalsEye ProteinsMiceMice, KnockoutRetinaRetinal Cone Photoreceptor CellsRetinaldehydeRetinal Pigment EpitheliumRetinal PigmentsRetinoidsRetinol-Binding ProteinsRetinol-Binding Proteins, CellularRetinol-Binding Proteins, InterstitialRhodopsinRod OpsinsVitamin AEye ProteinsRetinaldehydeRetinal PigmentsRetinoidsRetinol-Binding ProteinsRetinol-Binding Proteins, CellularRetinol-Binding Proteins, InterstitialRhodopsinRod OpsinsRrh protein, mouseVitamin Agene knock-outG protein-coupled receptor (GPCR)membranephotoreceptorretinaretinal metabolismretinoid-binding proteinretinolvitamin A

Identifiers

PMID29109151
PMCPMC5766940
OpenAlexW2767993782

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.