Evidence map›Paper›PMID 29109144›Full record

ArticleThe Journal of biological chemistry2017

Autophagic clearance of proteasomes in yeast requires the conserved sorting nexin Snx4.

Antonia A Nemec, Lauren A Howell, Anna K Peterson, Matthew A Murray, Robert J Tomko

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 2 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.

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  16. Proteasome condensate formation is driven by multivalent interactions with shuttle factors and ubiquitin chains.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Antonia A NemecFrom the Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida 32306.
Lauren A HowellFrom the Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida 32306.
Anna K PetersonFrom the Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida 32306.
Matthew A MurrayFrom the Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida 32306.
Robert J TomkoFrom the Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida 32306 robert.tomko@med.fsu.edu.
Florida State University · US

Funding

Engagement and Communication Between Proteasonal SubcomplexesR01GM118600 · NIGMS · FLORIDA STATE UNIVERSITY · PI ROBERT JOSEPH TOMKO · 2017 to 2026
$2.7M
NIGMS NIH HHS R01 GM118600
6 · The paper itself

Abstract

Turnover of the 26S proteasome by autophagy is an evolutionarily conserved process that governs cellular proteolytic capacity and eliminates inactive particles. In most organisms, proteasomes are located in both the nucleus and cytoplasm. However, the specific autophagy routes for nuclear and cytoplasmic proteasomes are unclear. Here, we investigate the spatial control of autophagic proteasome turnover in budding yeast (

Indexed as

AutophagyCell NucleusCytoplasmProteasome Endopeptidase ComplexProtein TransportSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSorting NexinsUbiquitinationATP dependent 26S proteaseProteasome Endopeptidase ComplexSaccharomyces cerevisiae ProteinsSorting Nexinsautophagyproteasomeprotein degradationproteolysissorting nexin (SNX)

Identifiers

PMID29109144
PMCPMC5766950
OpenAlexW2767892922

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.