ArticleEMBO molecular medicine2017
SOX9 predicts progression toward cirrhosis in patients while its loss protects against liver fibrosis.
Open access · goldAbstract read
In one paragraph
Article in EMBO molecular medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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0cells of the map it votes in
31citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
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Who cites it
31 citing papers in PubMed, 55 citations in OpenAlex.
- The impact of hypoxia and glycolysis on liver fibrosis.Journal of translational medicine · 2026Article
- Critical role of transcription factor SOX4 in tubular epithelial cell dedifferentiation and fibroblast activation during kidney fibrosis.Kidney international · 2026Article
- Spatial gene regulatory networks driving cell state transitions during human liver disease.EMBO molecular medicine · 2025Article
- SOX9 plays an essential role in myofibroblast driven hepatic granuloma integrity and parenchymal repair during schistosomiasis-induced liver damage.PLoS pathogens · 2025Article
- SOX9 Overexpression Ameliorates Metabolic Dysfunction-associated Steatohepatitis Through Activation of the AMPK Pathway.Journal of clinical and translational hepatology · 2025Article
- Molecular Mechanisms of Fibrosis in Cholestatic Liver Diseases and Regenerative Medicine-Based Therapies.Cells · 2024Review
- Profibrotic role of the SOX9-MMP10-ECM biosynthesis axis in the tracheal fibrosis after injury and repair.Genes & diseases · 2024Article
- Diverse functions of SOX9 in liver development and homeostasis and hepatobiliary diseases.Genes & diseases · 2024Review
- Article
- Mechanosensation to inflammation: Roles for YAP/TAZ in innate immune cells.Science signaling · 2023Review
- Wilms Tumor 1-Driven Fibroblast Activation and Subpleural Thickening in Idiopathic Pulmonary Fibrosis.International journal of molecular sciences · 2023Review
- Cellular and transcriptional heterogeneity in the intrahepatic biliary epithelium.Gastro hep advances · 2023Article
- Construction of a neural network diagnostic model for renal fibrosis and investigation of immune infiltration characteristics.Frontiers in immunology · 2023Article
- Unlocking the post-transplant microenvironment for successful islet function and survival.Frontiers in endocrinology · 2023Review
- Knockdown of SOX9 alleviates tracheal fibrosis through the Wnt/β-catenin signaling pathway.Journal of molecular medicine (Berlin, Germany) · 2022Article
- MicroRNA-15a inhibits hepatic stellate cell activation and proliferation via targeting SRY-box transcription factor 9.Bioengineered · 2022Article
- In vivo partial cellular reprogramming enhances liver plasticity and regeneration.Cell reports · 2022Article
- Yap-Sox9 signaling determines hepatocyte plasticity and lineage-specific hepatocarcinogenesis.Journal of hepatology · 2022Article
- Evaluation of SOX9-Positive Hepatocytes in Human Liver Specimens and Mature Mouse Hepatocytes.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Dysregulated overexpression of Sox9 induces fibroblast activation in pulmonary fibrosis.JCI insight · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 5 institutions in 2 countries.
Varinder S AthwalDivision of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
James PritchettSchool of Healthcare Science, Manchester Metropolitan University, Manchester, UK.
Jessica LlewellynDivision of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
Katherine MartinDivision of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
Elizabeth CamachoCentre for Health Economics, Institute of Population Health, Faculty of Medical & Human Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
Sayyid Ma RazaDivision of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
Alexander Phythian-AdamsManchester Centre for Collaborative Inflammation Research, Faculty of Life Sciences, University of Manchester, Manchester, UK.
Lindsay J BirchallDivision of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
Aoibheann F MullanDivision of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
Kim SuDivision of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
Laurence PearmainDivision of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
Grace DolmanNottingham Digestive Diseases Centre and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, UK.
Abed M ZaitounDepartment of Cellular Pathology, Nottingham Digestive Diseases Centre and National Institute of Health Research Biomedical Research Unit in Gastroenterology and Liver Disease, University of Nottingham and Nottingham University Hospitals NHS Trust, Nottingham, UK.
Scott L FriedmanDivision of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Andrew MacDonaldManchester Centre for Collaborative Inflammation Research, Faculty of Life Sciences, University of Manchester, Manchester, UK.ORCID 0000-0002-5356-1149
William L IrvingNottingham Digestive Diseases Centre and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, UK.
Indra N GuhaNottingham Digestive Diseases Centre and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, UK.
Neil A HanleyDivision of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
Karen Piper HanleyDivision of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK karen.piperhanley@manchester.ac.uk.ORCID 0000-0001-9473-9647
Manchester Academic Health Science Centre · GBNottingham University Hospitals NHS Trust · GBUniversity of Manchester · GBIcahn School of Medicine at Mount Sinai · USManchester Metropolitan University · GB
Funding
Medical Research Council G1001928Medical Research Council MR/J003352/1Medical Research Council MR/K003194/1Medical Research Council MR/N005953/1Medical Research Council MR/P023541/1Medical Research Council MR/R00191X/1Wellcome Trust WT088566MA
Abstract
Fibrosis and organ failure is a common endpoint for many chronic liver diseases. Much is known about the upstream inflammatory mechanisms provoking fibrosis and downstream potential for tissue remodeling. However, less is known about the transcriptional regulation
Indexed as
AnimalsBile DuctsCarbon TetrachlorideCells, CulturedDisease Models, AnimalDisease ProgressionFemaleHepatic Stellate CellsHumansLiverLiver CirrhosisLiver DiseasesMacrophagesMaleMiceMice, Inbred C57BLCarbon TetrachlorideSOX9 Transcription Factorextracellular matrixhepatic stellate cellsliver fibrosisSOX9YAP1
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.