ReviewJournal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology2018
The biomechanics of subsynovial connective tissue in health and its role in carpal tunnel syndrome.
Review in Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Impaired median nerve mobility in patients with carpal tunnel syndrome: a systematic review and meta-analysis.European radiology · 2023Pooled it
- Review
- Glucagon-Like Peptide-1 Receptor Agonist Therapy Associated With Fewer Diagnoses of Carpal Tunnel Syndrome Within 2 Years of Treatment.Hand (New York, N.Y.) · 2026Article
- Treatment Monitoring of Carpal Tunnel Syndrome Using Shear Wave Elastography: A Pilot In Vivo Study.Cureus · 2026Article
- Case Report: Ultrasound-guided hydrodissection targeting the subsynovial connective tissue with dynamic ultrasound assessment in refractory carpal tunnel syndrome: a report of two cases.Frontiers in medicine · 2026Article
- Article
- Correlation of body composition and anthropometric indices with electrodiagnostic and ultrasonographic findings in patients with carpal tunnel syndrome.BMC musculoskeletal disorders · 2025Article
- Grip Force Modulation on Median Nerve Morphology Changes.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Carpal tunnel syndrome.Nature reviews. Disease primers · 2024Review
- Genetic causal association between frozen shoulder and carpal tunnel syndrome: a two-sample mendelian randomization.BMC musculoskeletal disorders · 2024Article
- Higher densities of T-lymphocytes in the subsynovial connective tissue of people with carpal tunnel syndrome.PloS one · 2024Article
- Median nerve versus flexor tendons: visualization of median nerve level changes in the proximal carpal tunnel during wrist movement with dynamic high-resolution ultrasound.Journal of ultrasonography · 2023Article
- Potential Relationships between the Median Nerve Cross-Sectional Area and Physical Characteristics in Unilateral Symptomatic Carpal Tunnel Syndrome Patients.Journal of clinical medicine · 2023Article
- Ultrasonographical Evaluation of the Median Nerve Mobility in Carpal Tunnel Syndrome: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2022Article
- T2-weighted MRI defines critical compression in the distal carpal tunnel that is relieved after decompressive surgery.Journal of plastic, reconstructive & aesthetic surgery : JPRAS · 2022Article
- Ultrasound-guided percutaneous release procedures in the transverse carpal ligament by acupotomy: A cadaveric study.Frontiers in surgery · 2022Article
- An ultrasound study of the mobility of the median nerve during composite finger movement in the healthy young wrist.Muscle & nerve · 2022Article
- Carpal tunnel volume distribution and morphology changes with flexion-extension and radial-ulnar deviation wrist postures.PloS one · 2022Article
- Carpal tunnel syndrome treatment and the subsequent alterations in tendon and connective tissue dynamics.Clinical biomechanics (Bristol, Avon) · 2021Article
- Pathogenic Hydrogel? A Novel-Entrapment Neuropathy Model Induced by Ultrasound-Guided Perineural Injections.International journal of molecular sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Carpal Tunnel Syndrome (CTS) is the most common surgically treated problem in the hand. Aside from the neuropathy itself, the most common findings are fibrosis of the subsynovial connective tissue (SSCT) and increased intra carpal tunnel pressure. Normally, the SSCT is a multilayer tissue interspersed among the carpal tendons and nerve. As the tendons move, successive SSCT layers are recruited, forming a gliding unit and providing a limit to differential movement. Exceeding this limit, damages the SSCT as has been shown in both cadavers and animal models. This damage leads to a non-inflammatory response with progressive fibrosis and nerve ischemia leaving the SSCT more susceptible to injury. Although the direct consequences for patients are not fully understood, ultrasound research shows that this fibrosis restricts median nerve displacement during tendon loading. This article aims to provide insights into the mechanical properties of SSCT described so far and place it in the context of CTS pathophysiology. A theoretical damage model concerning the SSCT is proposed showing a chain of events and vicious cycles that could lead to the nerve compression as it is found in CTS. Although not complete, this model could explain the pathophysiological pathway of idiopathic CTS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.