Evidence map›Paper›PMID 29108851›Full record

ArticleJournal of biomechanics2017

Examining tissue composition, whole-bone morphology and mechanical behavior of Gorab

Haisheng Yang, Laia Albiol, Wing-Lee Chan, Dag Wulsten, Anne Seliger, Michael Thelen, Tobias Thiele, Lyudmila Spevak, Adele Boskey, Uwe Kornak and 2 more

Abstract read
In one paragraph

Article in Journal of biomechanics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

  1. Longitudinal Density and Volume Changes of Periacetabular Cancellous and Cortical Bone.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Article
  2. Tibial Biomechanics and Adaptive Response to Mechanical Stimuli in the Green Iguana.Integrative organismal biology (Oxford, England) · 2025
    Article
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  12. Murine Axial Compression Tibial Loading Model to Study Bone Mechanobiology: Implementing the Model and Reporting Results.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020
    Review
  13. Article
  14. Journal of the Royal Society, Interface · 2018
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Haisheng YangDepartment of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology, Beijing, China; Research Centre, Shriners Hospital for Children-Canada, Department of Pediatric Surgery, McGill University, Montreal, Canada.
Laia AlbiolJulius Wolff Institute, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Wing-Lee ChanInstitute for Medical Genetics and Human Genetics, Charité-Universitätsmedizin Berlin, Germany.
Dag WulstenJulius Wolff Institute, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Anne SeligerJulius Wolff Institute, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Michael ThelenInstitute for Medical Genetics and Human Genetics, Charité-Universitätsmedizin Berlin, Germany.
Tobias ThieleJulius Wolff Institute, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Lyudmila SpevakHospital for Special Surgery, NYC, USA.
Adele BoskeyHospital for Special Surgery, NYC, USA.
Uwe KornakInstitute for Medical Genetics and Human Genetics, Charité-Universitätsmedizin Berlin, Germany; Berlin-Brandenburg Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Germany; Max Planck Institute for Molecular Genetics, Berlin, Germany.
Sara ChecaJulius Wolff Institute, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Bettina M WillieResearch Centre, Shriners Hospital for Children-Canada, Department of Pediatric Surgery, McGill University, Montreal, Canada; Julius Wolff Institute, Charité-Universitätsmedizin Berlin, Berlin, Germany. Electronic address: bwillie@shriners.mcgill.ca.
Berlin Institute of Health at Charité - Universitätsmedizin Berlin · DECharité - Universitätsmedizin Berlin · DEHospital for Special Surgery · USBeijing University of Technology · CNMax Planck Institute for Molecular Genetics · DE

Funding

FT-IR MICROSCOPY OF MINERAL STRUCTURE IN OSTEOPOROSISR01AR041325 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI GOLDRING, MARY B · 1993 to 2017
$9.2M
TRABECULAR BONE ADAPTATION TO MECHANICAL LOADINGP30AR046121 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI MYERS, ELIZABETH R. · 1999 to 2010
$5.5M
NIAMS NIH HHS P30 AR046121NIAMS NIH HHS R01 AR041325
6 · The paper itself

Abstract

Gerodermia osteodysplastica (GO) is a segmental progeroid disorder caused by loss-of-function mutations in the GORAB gene, associated with early onset osteoporosis and bone fragility. A conditional mouse model of GO (Gorab

Indexed as

Adaptor Proteins, Vesicular TransportAging, PrematureAnimalsBiomechanical PhenomenaBone DensityBone DiseasesDisease Models, AnimalDNA-Binding ProteinsDwarfismFemaleFractures, BoneHomeodomain ProteinsMiceMice, Inbred C57BLMice, TransgenicProtein KinasesAdaptor Proteins, Vesicular TransportDNA-Binding ProteinsHomeodomain ProteinsProtein KinasesPrrx1 protein, mouseScyl1 protein, mouseBone compositionBone strengthFinite element analysisOsteoporosisPremature aging

Identifiers

PMID29108851
PMCPMC5695220
OpenAlexW2765985338

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.