Evidence map›Paper›PMID 29108701›Full record

ArticleSurgery2018

Impact of potassium iodide on thyroidectomy for Graves' disease: Implications for safety and operative difficulty.

Reese W Randle, Maria F Bates, Kristin L Long, Susan C Pitt, David F Schneider, Rebecca S Sippel

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04856488 (Preoperative Lugol's Solution in Graves' Disease and Toxic Nodular Goiter), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04856488 phase3recruitingnot on this mapstarted 2021, after this paper: background citation

Preoperative Lugol's Solution in Graves' Disease and Toxic Nodular Goiter

TypeinterventionalSponsorJan CalissendorffRan2021 to 2028Enrolled182ConditionsHyperthyroidismArmsIodine-Potassium Iodide 5%-10% Oral and Topical Solution
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 31 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Preoperative preparation for Graves' disease.Frontiers in endocrinology · 2023
    Review
  6. Article
  7. Management of Graves Thyroidal and Extrathyroidal Disease: An Update.The Journal of clinical endocrinology and metabolism · 2020
    Review
  8. Article
  9. Hyperthyroidism.Gland surgery · 2020
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Reese W RandleDepartment of Surgery, University of Wisconsin, Madison, WI. Electronic address: Reese.Randle@uky.edu.
Maria F BatesDepartment of Surgery, University of Wisconsin, Madison, WI.
Kristin L LongDepartment of Surgery, University of Wisconsin, Madison, WI.
Susan C PittDepartment of Surgery, University of Wisconsin, Madison, WI.
David F SchneiderDepartment of Surgery, University of Wisconsin, Madison, WI.
Rebecca S SippelDepartment of Surgery, University of Wisconsin, Madison, WI.
University of Wisconsin–Madison · US

Funding

Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
Institutional Clinical and Translational Science AwardKL2TR000428 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$6.2M
NCATS NIH HHS KL2 TR000428NCATS NIH HHS UL1 TR000427
6 · The paper itself

Abstract

backgroundPotassium iodide often is prescribed prior to thyroidectomy for Graves' disease, but the effect of potassium iodide on the ease and safety of thyroidectomy for Graves' is largely unknown.

methodsWe conducted a prospective, cohort study of patients with Graves' disease undergoing thyroidectomy. For the first 8 months, no patients received potassium iodide; for the next 8 months, potassium iodide was added to the preoperative protocol for all patients. Outcomes included operative difficulty (based on the Thyroidectomy Difficulty Scale) and complications.

resultsWe included a total of 31 patients in the no potassium iodide group and 28 in the potassium iodide group. According to the Thyroidectomy Difficulty Scale, gland vascularity decreased in the potassium iodide group (mean score 2.6 vs 3.3, P = .04), but there were no differences in friability, fibrosis, or size of the thyroid or in overall difficulty of operation (P = not significant for all). Despite similar operative difficulty, patients prescribed potassium iodide were less likely to experience transient hypoparathyroidism (7% vs 26%, P = .018) and transient hoarseness (0% vs 16%, P = .009) compared with the no potassium iodide group.

conclusionPotassium iodide administration decreases gland vascularity, but does not change the overall difficulty of thyroidectomy. Preoperative use of potassium iodide solution was, however, associated with less transient hypoparathyroidism and transient hoarseness, suggesting that potassium iodide improves the safety of thyroidectomy for Graves' disease.

Indexed as

AdultFemaleGraves DiseaseHumansMaleMiddle AgedPostoperative ComplicationsPotassium IodideProspective StudiesThyroidectomyWisconsinYoung AdultPotassium Iodide

Identifiers

PMID29108701
PMCPMC5736456
OpenAlexW2765372505

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.