Evidence map›Paper›PMID 29108364›Full record

ArticleOncotarget2017

The impact of post-radioiodine therapy SPECT/CT on early risk stratification in differentiated thyroid cancer; a bi-institutional study.

Szabina Szujo, Livia Sira, Laszlo Bajnok, Beata Bodis, Ferenc Gyory, Orsolya Nemes, Karoly Rucz, Peter Kenyeres, Zsuzsanna Valkusz, Krisztian Sepp and 7 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. The Diagnostic Usefulness ofDiagnostics (Basel, Switzerland) · 2021
    Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Szabina SzujoIst Department of Medicine, University of Pecs, H-7624 Pecs, Hungary.
Livia SiraDepartment of Medicine, Faculty of Medicine, University of Debrecen, H-4012 Debrecen, Hungary.
Laszlo BajnokIst Department of Medicine, University of Pecs, H-7624 Pecs, Hungary.
Beata BodisIst Department of Medicine, University of Pecs, H-7624 Pecs, Hungary.
Ferenc GyoryDepartment of Surgery, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Orsolya NemesIst Department of Medicine, University of Pecs, H-7624 Pecs, Hungary.
Karoly RuczIst Department of Medicine, University of Pecs, H-7624 Pecs, Hungary.
Peter KenyeresIst Department of Medicine, University of Pecs, H-7624 Pecs, Hungary.
Zsuzsanna ValkuszIst Department of Medicine, University of Szeged, H-6720 Szeged, Hungary.
Krisztian SeppIst Department of Medicine, University of Szeged, H-6720 Szeged, Hungary.
Erzsebet SchmidtDepartment of Nuclear Medicine, University of Pecs, H-7624 Pecs, Hungary.
Zsuszanna SzaboDepartment of Nuclear Medicine, University of Pecs, H-7624 Pecs, Hungary.
Sarolta SzekeresDepartment of Nuclear Medicine, University of Pecs, H-7624 Pecs, Hungary.
Katalin ZamboDepartment of Nuclear Medicine, University of Pecs, H-7624 Pecs, Hungary.
Sandor BarnaDepartment of Nuclear Medicine, Faculty of Medicine, University of Debrecen, H-4012 Debrecen, Hungary.
Endre V NagyDepartment of Medicine, Faculty of Medicine, University of Debrecen, H-4012 Debrecen, Hungary.
Emese MezosiIst Department of Medicine, University of Pecs, H-7624 Pecs, Hungary.
University of Pecs · HUUniversity of Debrecen · HUUniversity of Szeged · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveSPECT/CT has numerous advantages over planar and traditional SPECT images. The aim of this study was to evaluate the role of post-radioiodine therapy SPECT/CT of patients with differentiated thyroid cancer (DTC) in early risk classification and in prediction of late prognosis. PATIENTS AND

methods323 consecutive patients were investigated after their first radioiodine treatment (1100-3700 MBq). Both whole body scan and SPECT/CT images of the head, neck, chest and abdomen regions were taken 4-6 days after radioiodine therapy. Patients were re-evaluated 9-12 months later as well as at the end of follow up (median 37 months).

resultsPost-radioiodine therapy SPECT/CT showed metastases in 22% of patients. Lymph node, lung and bone metastases were detected in 61, 13 and 5 patients, respectively, resulting in early reclassification of 115 cases (36%). No evidence of disease was found in 251 cases at 9-12 months after radioiodine treatment and 269 patients at the end of follow-up. To predict residual disease at the end of follow-up, the sensitivities, specificities and diagnostic accuracies of the current risk classification systems and SPECT/CT were: ATA: 77%, 47% and 53%; ETA: 70%, 62% and 64%; SPECT/CT: 61%, 88% and 83%, respectively. There was no difference between cohorts of the two institutions when data were analyzed separately.

conclusionsBased on our bi-institutional experience, the accuracy of post-radioiodine SPECT/CT outweighs that of the currently used ATA and ETA risk classification systems in the prediction of long-term outcome of DTC.

Indexed as

ATA risk classificationdifferentiated thyroid cancerETA risk classificationradioiodine therapySPECT/CT

Identifiers

PMID29108364
PMCPMC5668097
OpenAlexW2626926653

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.