Evidence map›Paper›PMID 29108255›Full record

ArticleOncotarget2017

Comprehensive bioinformatics analysis of the characterization and determination underlying mechanisms of over-expression and co-expression of genes residing on 20q in colorectal cancer.

Daojiang Li, Changwei Lin, Miao Chen, Nanpeng Li, Yuheng Du, Chen Su, Chunxing Yang, Ni Gong, Hao Wu, Runliu Wu and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. The N6-Methyladenosine (m6A) Methylation GeneCancer management and research · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Daojiang LiDepartment of General Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
Changwei LinDepartment of General Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
Miao ChenDepartment of General Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
Nanpeng LiDepartment of General Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
Yuheng DuDepartment of General Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
Chen SuDepartment of General Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
Chunxing YangDepartment of General Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
Ni GongDepartment of General Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
Hao WuDepartment of General Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
Runliu WuDepartment of General Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
Arad JainCollege of Arts and Science, University of Virginia, Charlottesville, Virginia 22904, The United States of America.
Yi ZhangDepartment of General Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
Xiaorong LiDepartment of General Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
Central South University · CNThird Xiangya Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Long arm of chromosome 20 (20q) is closely related to the development of colorectal cancer, so identifying the expression profile of genes on 20q through a comprehensive overview is indispensable. In this article, preliminar experimental data, several available databases and bioinformatics tools such as the Cancer Genome Atlas, the Encyclopedia of DNA Elements, the JASPAR database and starBase were combined to analyze the correlation between genes and chromosomal aberrations, microRNA and transcription factors, as well as to explore the expression feature and potential regulative mechanism. The results showed that the most frequently unregulated genes in colorectal cancer arelocated on chromosome 20q, present a significant CNA-mRNA correlation.Furthermore, the genes with mRNA overexpression showed co-expression features and tended to be clustered within the same genomic neighborhoods. Then, several genes were selected to carry out further analysis and demonstrated that shared transcription factors, a conserved bidirectional promoter, and competition for a limited pool of microRNAin the 3'UTR of mRNA may be the underlying mechanisms behind the co-expression of physically adjacent genes.Finally, the databases, Lentivirus shRNA, and qPCR were used to find that these adjacent genes with co-expression cooperatively participated in the same biological pathways associated with the pathogenesis and development of colorectal cancer.

Indexed as

20qadjacent geneCNAco-expressioncolorectal cancer

Identifiers

PMID29108255
PMCPMC5667988
OpenAlexW2744219985

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.