ArticlePLoS genetics2017
Hippo, TGF-β, and Src-MAPK pathways regulate transcription of the upd3 cytokine in Drosophila enterocytes upon bacterial infection.
Article in PLoS genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 93 citations in OpenAlex.
- Damage recognition by intestinal stem cells via Draper promotes adult Drosophila midgut regeneration.The EMBO journal · 2026Article
- Gut-derived Unpaired-3 cytokine signaling promotes systemic hypoxia tolerance in Drosophila.Disease models & mechanisms · 2026Article
- TF2TG: an online resource mining the potential gene targets of transcription factors in Drosophila.Genetics · 2026Article
- Glycolytic disruption restricts Drosophila melanogaster larval growth via the cytokine Upd3.PLoS genetics · 2025Article
- A feedback loop between Paxillin and Yorkie sustains Drosophila intestinal homeostasis and regeneration.Nature communications · 2025Article
- Host-Microbe Interactions in Drosophila Cancer.Advances in experimental medicine and biology · 2025Review
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- Piperonyl butoxide elicits a robust transcriptional response in adult Drosophila melanogaster.Pesticide biochemistry and physiology · 2024Article
- Inter-cell type interactions that control JNK signaling in the Drosophila intestine.Nature communications · 2024Article
- Host-Microbe Interactions Regulate Intestinal Stem Cells and Tissue Turnover inInternational journal of stem cells · 2024Review
- Bleomycin reducesMicrobiology spectrum · 2024Article
- The midgut epithelium of mosquitoes adjusts cell proliferation and endoreplication to respond to physiological challenges.BMC biology · 2024Article
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- Insights into midgut cell types and their crucial role in antiviral immunity in the lepidopteran modelFrontiers in immunology · 2024Review
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- Combining stem cell rejuvenation and senescence targeting to synergistically extend lifespan.Aging · 2022Article
- Rab21 in enterocytes participates in intestinal epithelium maintenance.Molecular biology of the cell · 2022Article
- Microbes affect gut epithelial cell composition through immune-dependent regulation of intestinal stem cell differentiation.Cell reports · 2022Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 5 countries.
Funding
Abstract
Cytokine signaling is responsible for coordinating conserved epithelial regeneration and immune responses in the digestive tract. In the Drosophila midgut, Upd3 is a major cytokine, which is induced in enterocytes (EC) and enteroblasts (EB) upon oral infection, and initiates intestinal stem cell (ISC) dependent tissue repair. To date, the genetic network directing upd3 transcription remains largely uncharacterized. Here, we have identified the key infection-responsive enhancers of the upd3 gene and show that distinct enhancers respond to various stresses. Furthermore, through functional genetic screening, bioinformatic analyses and yeast one-hybrid screening, we determined that the transcription factors Scalloped (Sd), Mothers against dpp (Mad), and D-Fos are principal regulators of upd3 expression. Our study demonstrates that upd3 transcription in the gut is regulated by the activation of multiple pathways, including the Hippo, TGF-β/Dpp, and Src, as well as p38-dependent MAPK pathways. Thus, these essential pathways, which are known to control ISC proliferation cell-autonomously, are also activated in ECs to promote tissue turnover the regulation of upd3 transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.