ArticlePLoS biology2017
Stochastic loss and gain of symmetric divisions in the C. elegans epidermis perturbs robustness of stem cell number.
Article in PLoS biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- HDAC1/2-mediated repression of Wnt receptor expression orients asymmetric division polarity in Caenorhabditis elegans.Development (Cambridge, England) · 2026Article
- Transcriptional feedback targeting Wnt pathway components reveals hidden heterogeneity in Caenorhabditis elegans seam cell lineages.Genetics · 2026Article
- Induction of host genes by nested genes duringiScience · 2025Article
- Article
- EFL-3/E2F7 modulates Wnt signalling by repressing the Nemo-like kinase LIT-1 during asymmetric epidermal cell division in Caenorhabditis elegans.Development (Cambridge, England) · 2025Article
- Article
- LTP2 hypomorphs show genotype-by-environment interaction in early seedling traits in Arabidopsis thaliana.The New phytologist · 2024Article
- Article
- Article
- PRC1 chromatin factors strengthen the consistency of neuronal cell fate specification and maintenance in C. elegans.PLoS genetics · 2022Article
- Targeted DamID inScience advances · 2022Article
- Gene-Environment Interactions and Stochastic Variations in the Gero-Exposome.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Gene expression profiling of epidermal cell types in C. elegans using Targeted DamID.Development (Cambridge, England) · 2021Article
- Cryptic genetic variation in a heat shock protein modifies the outcome of a mutation affecting epidermal stem cell development in C. elegans.Nature communications · 2021Article
- Phenotypic Robustness of Epidermal Stem Cell Number inFrontiers in cell and developmental biology · 2021Article
- Article
- Robust organ size requires robust timing of initiation orchestrated by focused auxin and cytokinin signalling.Nature plants · 2020Article
- A Cell Fate Switch in theGenetics · 2020Article
- A Myt1 family transcription factor defines neuronal fate by repressing non-neuronal genes.eLife · 2019Article
- New alleles of the lin-22/Hairy bHLH transcription factor.microPublication biology · 2019Article
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11 authors.
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Abstract
Biological systems are subject to inherent stochasticity. Nevertheless, development is remarkably robust, ensuring the consistency of key phenotypic traits such as correct cell numbers in a certain tissue. It is currently unclear which genes modulate phenotypic variability, what their relationship is to core components of developmental gene networks, and what is the developmental basis of variable phenotypes. Here, we start addressing these questions using the robust number of Caenorhabditis elegans epidermal stem cells, known as seam cells, as a readout. We employ genetics, cell lineage tracing, and single molecule imaging to show that mutations in lin-22, a Hes-related basic helix-loop-helix (bHLH) transcription factor, increase seam cell number variability. We show that the increase in phenotypic variability is due to stochastic conversion of normally symmetric cell divisions to asymmetric and vice versa during development, which affect the terminal seam cell number in opposing directions. We demonstrate that LIN-22 acts within the epidermal gene network to antagonise the Wnt signalling pathway. However, lin-22 mutants exhibit cell-to-cell variability in Wnt pathway activation, which correlates with and may drive phenotypic variability. Our study demonstrates the feasibility to study phenotypic trait variance in tractable model organisms using unbiased mutagenesis screens.
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