Evidence map›Paper›PMID 29107896›Full record

ReviewCurrent opinion in microbiology2018

CryoEM-based hybrid modeling approaches for structure determination.

C Keith Cassidy, Benjamin A Himes, Zaida Luthey-Schulten, Peijun Zhang

Open access · bronzeAbstract readReview
In one paragraph

Review in Current opinion in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Recent structural advances in bacterial chemotaxis signalling.Current opinion in structural biology · 2023
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. mBio · 2019
    Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

C Keith CassidyDepartment of Physics, Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Benjamin A HimesDepartment of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Zaida Luthey-SchultenDepartment of Chemistry, Center for the Physics of Living Cells, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Peijun ZhangDepartment of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK; Electron Bio-Imaging Centre, Diamond Light Sources, Harwell Science and Innovation Campus, Didcot OX11 0DE, UK. Electronic address: peijun@strubi.ox.ac.uk.
University of Illinois Urbana-Champaign · USUniversity of Pittsburgh · US

Funding

WHOLE CELL SIMULATIONP41GM104601 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI TAJKHORSHID, EMAD · 2012 to 2021
$19.0M
Structure and function of membrane receptor signaling complex in bacterial chemotR01GM085043 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZHANG, PEIJUN · 2009 to 2013
$1.4M
NIGMS NIH HHS P41 GM104601NIGMS NIH HHS R01 GM085043Wellcome TrustWellcome Trust 206422/Z/17/Z
6 · The paper itself

Abstract

Recent advances in cryo-electron microscopy (cryoEM) have dramatically improved the resolutions at which vitrified biological specimens can be studied, revealing new structural and mechanistic insights over a broad range of spatial scales. Bolstered by these advances, much effort has been directed toward the development of hybrid modeling methodologies for the construction and refinement of high-fidelity atomistic models from cryoEM data. In this brief review, we will survey the key elements of cryoEM-based hybrid modeling, providing an overview of available computational tools and strategies as well as several recent applications.

Indexed as

Models, MolecularComputational BiologyComputer SimulationCryoelectron MicroscopyProtein Conformation

Identifiers

PMID29107896
PMCPMC5934336
OpenAlexW2765116378

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.