ArticleNeurobiology of aging2018
The FBN rat model of aging: investigation of ABR waveforms and ribbon synapse changes.
Article in Neurobiology of aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 60 citations in OpenAlex.
- Article
- Age-related ultrastructural differences in the dorsal cortex of the inferior colliculus in the fischer brown Norway rat.Neurobiology of aging · 2026Article
- Age-related differences in asymmetric synapses across the central inferior colliculus in the Fischer Brown Norway rat.Aging brain · 2026Article
- Age-related differences in GABAergic synapses across the central inferior colliculus in the Fischer Brown Norway rat.Neurobiology of aging · 2025Article
- Age-Related Decline of Gastric Secretion: Facts and Controversies.Biomedicines · 2025Review
- Sound-evoked plasticity differentiates tinnitus from non-tinnitus mice.Frontiers in neuroscience · 2025Article
- Neuropeptide Y mRNA expression in the aging inferior colliculus of fischer brown norway rats.Frontiers in aging neuroscience · 2025Article
- Article
- Resistance to age-related hearing loss in the echolocating big brown bat (Proceedings. Biological sciences · 2024Article
- Cochlear Ribbon Synapses in Aged Gerbils.International journal of molecular sciences · 2024Article
- Age-related upregulation of dense core vesicles in the central inferior colliculus.Frontiers in cellular neuroscience · 2024Article
- Sheep as a large animal model for hearing research: comparison to common laboratory animals and humans.Laboratory animal research · 2023Review
- Age-related changes in auditory perception. Hearing loss in the elderly: aging ear or aging brain?Aging clinical and experimental research · 2023Review
- Article
- Age-related upregulation of perineuronal nets on inferior collicular cells that project to the cochlear nucleus.Frontiers in aging neuroscience · 2023Article
- Age-related Changes of GAD1 mRNA Expression in the Central Inferior Colliculus.Translational medicine of aging · 2023Article
- Age-related ultrastructural changes in the lateral cortex of the inferior colliculus.Neurobiology of aging · 2022Article
- Age-related central gain with degraded neural synchrony in the auditory brainstem of mice and humans.Neurobiology of aging · 2022Article
- Deafness-in-a-dish: modeling hereditary deafness with inner ear organoids.Human genetics · 2022Review
- Corticothalamic projections deliver enhanced responses to medial geniculate body as a function of the temporal reliability of the stimulus.The Journal of physiology · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
Age-related hearing loss is experienced by one-third of individuals aged 65 years and older and can be socially debilitating. Historically, there has been poor correlation between age-related threshold changes, loss of speech understanding, and loss of cochlear hair cells. We examined changes in ribbon synapse number at four different ages in Fisher Brown Norway rats, an extensively studied rat model of aging. In contrast to previous work in mice/Wistar rats, we found minimal ribbon synapse loss before 20 months, with significant differences in 24- and 28-month-old rats at 4 kHz. Significant outer HC loss was observed at 24 and 28 months in low- to mid-frequency regions. Age-related reductions in auditory brainstem response wave I amplitude and increases in threshold were strongly correlated with ribbon synapse loss. Wave V/I ratios increased across age for click, 2, 4, and 24 kHz. Together, we find that ribbon synapses in the Fisher Brown Norway rat cochlea show resistance to aging until ∼60% of their life span, suggesting species/strain differences may underpin decreased peripheral input into the aging central processor.
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