Evidence map›Paper›PMID 29107709›Full record

Trial reportGastroenterology2017

IFNL4 Genotype Is Associated With Virologic Relapse After 8-Week Treatment With Sofosbuvir, Velpatasvir, and Voxilaprevir.

Thomas R O'Brien, Shyam Kottilil, Ruth M Pfeiffer

Abstract readLetterRandomized Controlled Trial
In one paragraph

Trial report in Gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2023
    Article
  6. Article
  7. Tropical medicine and infectious disease · 2022
    Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Meeting Overview: Interferon Lambda-Disease Impact and Therapeutic Potential.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2019
    Article
  13. What Have We Learned from Studies of IFN-λ Variants and Hepatitis C Virus Infection?Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2019
    Review
  14. Virusdisease · 2019
    Article
  15. [Chronic hepatitis C: achievement, challenge and strategy to eliminate as a public health threat].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Thomas R O'BrienInfections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.
Shyam KottililDivision of Clinical Care and Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland.
Ruth M PfeifferBiostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.

Funding

Epidemiology of Oncogenic VirusesZIACP005782 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI O'BRIEN, THOMAS R · 2009 to 2025
$6.7M
EPIDEMIOLOGY OF ONCOGENIC VIRUSESZ01CP005782 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI O'BRIEN, THOMAS R · 1996 to 2008
$1.4M
Intramural NIH HHS Z01 CP005782
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Aminoisobutyric AcidsCarbamatesCyclopropanesDrug CombinationsGenotypeHepacivirusHepatitis C, ChronicHeterocyclic Compounds, 4 or More RingsHumansInterferon LambdaInterleukinsLactams, MacrocyclicLeucineMacrocyclic CompoundsProlineQuinoxalinesAminoisobutyric AcidsCarbamatesCyclopropanesDrug CombinationsHeterocyclic Compounds, 4 or More RingsIFNL4 protein, humanInterferon LambdaInterleukinsLactams, MacrocyclicLeucineMacrocyclic CompoundsProlineQuinoxalinesSofosbuvirsofosbuvir-velpatasvir drug combinationSulfonamidesvoxilaprevir

Identifiers

PMID29107709
PMCPMC7390973

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.