ArticleStem cell reports2017
Default Patterning Produces Pan-cortical Glutamatergic and CGE/LGE-like GABAergic Neurons from Human Pluripotent Stem Cells.
Article in Stem cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- The protein interactome of the Neuron Specific Gene family (NSG1-3).bioRxiv : the preprint server for biology · 2025Article
- 3D cultured human medium spiny neurons functionally integrate and rescue motor deficits in Huntington's disease mice.The Journal of clinical investigation · 2025Article
- Directed and efficient generation of calretinin interneurons from human pluripotent stem cells.Stem cell research & therapy · 2025Article
- Patterning ganglionic eminences in developing human brain organoids using a morphogen-gradient-inducing device.Cell reports methods · 2024Article
- Cell type specification and diversity in subpallial organoids.Frontiers in genetics · 2024Review
- Understanding and modeling regional specification of the human ganglionic eminence.Stem cell reports · 2023Article
- Transcriptomic changes due to early, chronic intermittent alcohol exposure during forebrain development implicate WNT signaling, cell-type specification, and cortical regionalization as primary determinants of fetal alcohol syndrome.Alcoholism, clinical and experimental research · 2021Article
- Variable Outcomes in Neural Differentiation of Human PSCs Arise from Intrinsic Differences in Developmental Signaling Pathways.Cell reports · 2020Article
- Article
- Functionalization of Brain Region-specific Spheroids with Isogenic Microglia-like Cells.Scientific reports · 2019Article
- Induced pluripotent stem cells (iPSCs) as model to study inherited defects of neurotransmission in inborn errors of metabolism.Journal of inherited metabolic disease · 2018Review
- A Chemical Recipe for Generation of Clinical-Grade Striatal Neurons from hESCs.Stem cell reports · 2018Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Default differentiation of human pluripotent stem cells has been promoted as a model of cortical development. In this study, a developmental transcriptome analysis of default-differentiated hPSNs revealed a gene expression program resembling in vivo CGE/LGE subpallial domains and GABAergic signaling. A combination of bioinformatic, functional, and immunocytochemical analysis further revealed that hPSNs consist of both cortical glutamatergic and CGE-like GABAergic neurons. This study provides a comprehensive characterization of the heterogeneous group of neurons produced by default differentiation and insight into future directed differentiation strategies.
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Registered trials
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