Evidence map›Paper›PMID 29107561›Full record

SynthesisThe lancet. HIV2018

Association of antiretroviral therapy with high-risk human papillomavirus, cervical intraepithelial neoplasia, and invasive cervical cancer in women living with HIV: a systematic review and meta-analysis.

Helen Kelly, Helen A Weiss, Yolanda Benavente, Silvia de Sanjose, Philippe Mayaud, ART and HPV Review Group

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The lancet. HIV, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 176 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
176citing papers in PubMed, 11 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

176 citing papers in PubMed, 11 syntheses or guidelines pooled it, 292 citations in OpenAlex.

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116 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Helen KellyClinical Research Department, London School of Hygiene & Tropical Medicine, London, UK. Electronic address: helen.kelly@lshtm.ac.uk.
Helen A WeissMRC Tropical Epidemiology Group, London School of Hygiene & Tropical Medicine, London, UK.
Yolanda BenaventeCancer Epidemiology Research Program, Catalan Institute of Oncology, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
Silvia de SanjoseCIBER en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
Philippe MayaudClinical Research Department, London School of Hygiene & Tropical Medicine, London, UK.
ART and HPV Review Group
London School of Hygiene & Tropical Medicine · GBCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública · ESInstitut d'Investigació Biomédica de Bellvitge · ES

Funding

Medical Research Council MR/K012126/1
6 · The paper itself

Abstract

backgroundThe interactions between antiretroviral therapy (ART) and high-risk human papillomavirus (HPV) and cervical lesions in women living with HIV are poorly understood. We reviewed the association of ART with these outcomes.

methodsWe did a systematic review and meta-analysis by searching MEDLINE and Embase databases for cross-sectional or cohort studies published in English between Jan 1, 1996, and May 6, 2017, which reported the association of ART with prevalence of high-risk HPV or prevalence, incidence, progression, or regression of histological or cytological cervical abnormalities, or incidence of invasive cervcal cancer. Studies were eligible if they reported the association of combination ART or highly active ART use with the following outcomes: high-risk HPV prevalence; squamous intraepithelial lesion (SIL) or cervical intraepithelial neoplasia (CIN) prevalence, incidence, progression, or regression; and invasive cervical cancer incidence among women living with HIV. We did random-effects meta-analyses to estimate summary statistics. We examined heterogeneity with the I

findingsWe identified 31 studies of the association of ART with prevalence of high-risk HPV (6537 women living with HIV) and high grade cervical lesions (HSIL-CIN2+; 9288 women living with HIV). Women living with HIV on ART had lower prevalence of high-risk HPV than did those not on ART (adjusted odds ratio [aOR] 0·83, 95% CI 0·70-0·99; I

interpretationEarly ART initiation and sustained adherence is likely to reduce incidence and progression of SIL and CIN and ultimately incidence of invasive cervical cancer. Future cohort studies should aim to confirm this possible effect.

fundingUK Medical Research Council.

Indexed as

AdultAgedAntiretroviral Therapy, Highly ActiveFemaleHIV InfectionsHumansIncidenceMedication AdherenceMiddle AgedPapillomavirus InfectionsPrevalenceUterine Cervical DysplasiaUterine Cervical Neoplasms

Identifiers

PMID29107561
PMCPMC5757426
OpenAlexW2765445603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.