ArticleDevelopmental cell2017
Genetic Intersection of Tsix and Hedgehog Signaling during the Initiation of X-Chromosome Inactivation.
Article in Developmental cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Article
- FGF4 initiates X-chromosome inactivation via activating YY1 and prompting loss of pluripotency factors.The EMBO journal · 2026Article
- Multiscale chromatin modeling of chromosome X structural changes upon inactivation highlights the differential regulatory mechanism ofbioRxiv : the preprint server for biology · 2026Article
- Detection of Long Non-Coding RNA Localization by RNA Fluorescence In Situ Hybridization (FISH).Methods in molecular biology (Clifton, N.J.) · 2026Article
- LncRNA HOTTIP modulated by Hedgehog signaling drives colorectal cancer progression by promoting HUWE1-mediated ubiquitin‒proteasome degradation of p53.Cell death & disease · 2025Article
- Controlled X-chromosome dynamics defines meiotic potential of female mouse in vitro germ cells.The EMBO journal · 2022Article
- Activation of Xist by an evolutionarily conserved function of KDM5C demethylase.Nature communications · 2022Article
- Preventing erosion of X-chromosome inactivation in human embryonic stem cells.Nature communications · 2022Article
- Loss of Hilnc prevents diet-induced hepatic steatosis through binding of IGF2BP2.Nature metabolism · 2021Article
- Chromosome compartments on the inactive X guide TAD formation independently of transcription during X-reactivation.Nature communications · 2021Article
- Sexual Dimorphism of the Heart: Genetics, Epigenetics, and Development.Frontiers in cardiovascular medicine · 2021Review
- Decapping enzyme 1A breaks X-chromosome symmetry by controlling Tsix elongation and RNA turnover.Nature cell biology · 2020Article
- Serum RNA Profiling in the 10-Years Period Prior to Diagnosis of Testicular Germ Cell Tumor.Frontiers in oncology · 2020Article
- PRC1 collaborates with SMCHD1 to fold the X-chromosome and spread Xist RNA between chromosome compartments.Nature communications · 2019Article
- SMCHD1 Merges Chromosome Compartments and Assists Formation of Super-Structures on the Inactive X.Cell · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
X-chromosome inactivation (XCI) silences one X chromosome in the female mammal and is essential to peri-implantation development. XCI is thought to be cell autonomous, with all factors required being produced within each cell. Nevertheless, external cues may exist. Here, we search for such developmental signals by combining bioinformatic, biochemical, and genetic approaches. Using ex vivo and in vivo models, we identify the Hedgehog (HH) paracrine system as a candidate signaling cascade. HH signaling keeps XCI in check in pluripotent cells and is transduced by GLI transcription factors to binding sites in Tsix, the antisense repressor of XCI. GLI potentiates Tsix expression and impedes XCI. In vivo, mutating Indian Hedgehog results in a sex ratio bias against females, and the female lethality is rescued by a second-site mutation in Tsix. These data demonstrate a genetic and functional intersection between HH and XCI and support a role for intercellular signaling during XCI.
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Registered trials
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