ArticleDevelopmental cell2017
Boundary Formation through a Direct Threshold-Based Readout of Mobile Small RNA Gradients.
Article in Developmental cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
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- Integrated analysis of ATAC-seq and RNA-seq reveals the TCP-ARF molecular module related to pathogenic process of phytoplasma infection in Paulownia fortunei.BMC genomics · 2026Article
- The tasiR-ARF pathway in plants: origin, functions, and interplay of miR-390, tasiRNAs and ARF3.Plant biology (Stuttgart, Germany) · 2026Review
- Three decades of mobile RNA silencing within plants: what have we learnt?Journal of experimental botany · 2026Review
- Uncovering the Role of thePlants (Basel, Switzerland) · 2025Article
- Self-organization underlies developmental robustness in plants.Cells & development · 2025Review
- Perturbation of periodic spot-generation balance leads to diversified pigmentation patterning of harlequin Phalaenopsis orchids: in silico prediction.BMC plant biology · 2024Article
- A diffusible small-RNA-based Turing system dynamically coordinates organ polarity.Nature plants · 2024Article
- Beyond Loading: Functions of Plant ARGONAUTE Proteins.International journal of molecular sciences · 2023Review
- Physiological Control and Genetic Basis of Leaf Curvature and Heading in Brassica rapa L.Journal of advanced research · 2023Review
- microRNA165 and 166 modulate response of the Arabidopsis root apical meristem to salt stress.Communications biology · 2023Article
- The START domain potentiates HD-ZIPIII transcriptional activity.The Plant cell · 2023Article
- Diversification of ranunculaceous petals in shape supports a generalized model for plant lateral organ morphogenesis and evolution.Science advances · 2023Article
- Size regulation of the lateral organ initiation zone and its role in determining cotyledon number in conifers.Frontiers in plant science · 2023Article
- Polar auxin transport modulates early leaf flattening.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Eco-Evo-Devo of petal pigmentation patterning.Essays in biochemistry · 2022Article
- Insights into Mobile Small-RNAs Mediated Signaling in Plants.Plants (Basel, Switzerland) · 2022Review
- Molecular mechanisms underlying leaf development, morphological diversification, and beyond.The Plant cell · 2022Review
- Coactivation of antagonistic genes stabilizes polarity patterning during shoot organogenesis.Science advances · 2022Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Small RNAs have emerged as a new class of mobile signals. Here, we investigate their mechanism of action and show that mobile small RNAs generate sharply defined domains of target gene expression through an intrinsic and direct threshold-based readout of their mobility gradients. This readout is highly sensitive to small RNA levels at the source, allowing plasticity in the positioning of a target gene expression boundary. Besides patterning their immediate targets, the readouts of opposing small RNA gradients enable specification of robust, uniformly positioned developmental boundaries. These patterning properties of small RNAs are reminiscent of those of animal morphogens. However, their mode of action and the intrinsic nature of their gradients distinguish mobile small RNAs from classical morphogens and present a unique direct mechanism through which to relay positional information. Mobile small RNAs and their targets thus emerge as highly portable, evolutionarily tractable regulatory modules through which to create pattern.
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