Evidence map›Paper›PMID 29107538›Full record

ArticleMolecular cell2017

Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex.

Ming-Yuan Su, Kyle L Morris, Do Jin Kim, Yangxue Fu, Rosalie Lawrence, Goran Stjepanovic, Roberto Zoncu, James H Hurley

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed.

  1. Architecture of the human KICSTOR and GATOR1-KICSTOR complexes.Nature structural & molecular biology · 2025
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Making PI3K superfamily enzymes run faster.Advances in biological regulation · 2025
    Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
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  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Ming-Yuan SuDepartment of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA 94720, USA.
Kyle L MorrisDepartment of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA 94720, USA.
Do Jin KimDepartment of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA 94720, USA.
Yangxue FuDepartment of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA 94720, USA.
Rosalie LawrenceDepartment of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA 94720, USA.
Goran StjepanovicDepartment of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA 94720, USA; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Roberto ZoncuDepartment of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA 94720, USA; The Paul F. Glenn Center for Aging Research at the University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: rzoncu@berkeley.edu.
James H HurleyDepartment of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA 94720, USA; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. Electronic address: jimhurley@berkeley.edu.

Funding

THE MOLECULAR BASIS OF CELL FUNCTIONT32GM007232 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BILDER, DAVID, UNAL, ELCIN · 1985 to 2022
$36.4M
ENGINEERING ORGANELLE FUNCTION TO REWIRE CANCER CELL METABOLISMDP2CA195761 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI ZONCU, ROBERTO · 2014 to 2014
$2.4M
NCI NIH HHS DP2 CA195761NIGMS NIH HHS T32 GM007232
6 · The paper itself

Abstract

The lysosomal membrane is the locus for sensing cellular nutrient levels, which are transduced to mTORC1 via the Rag GTPases and the Ragulator complex. The crystal structure of the five-subunit human Ragulator at 1.4 Å resolution was determined. Lamtor1 wraps around the other four subunits to stabilize the assembly. The Lamtor2:Lamtor3 dimer stacks upon Lamtor4:Lamtor5 to create a platform for Rag binding. Hydrogen-deuterium exchange was used to map the Rag binding site to the outer face of the Lamtor2:Lamtor3 dimer and to the N-terminal intrinsically disordered region of Lamtor1. EM was used to reconstruct the assembly of the full-length RagA

Indexed as

Adaptor Proteins, Signal TransducingBinding SitesCarrier ProteinsGuanine Nucleotide Exchange FactorsHumansIntracellular Signaling Peptides and ProteinsMechanistic Target of Rapamycin Complex 1Microscopy, ElectronMolecular Docking SimulationMonomeric GTP-Binding ProteinsProtein BindingProtein Interaction Domains and MotifsProtein MultimerizationRecombinant ProteinsStructure-Activity RelationshipAdaptor Proteins, Signal TransducingCarrier ProteinsGuanine Nucleotide Exchange FactorsIntracellular Signaling Peptides and ProteinsLAMTOR1 protein, humanLAMTOR2 protein, humanLAMTOR3 protein, humanLAMTOR4 protein, humanLAMTOR5 protein, humanMechanistic Target of Rapamycin Complex 1Monomeric GTP-Binding ProteinsRecombinant ProteinsRRAGA protein, humanRRAGC protein, human

Identifiers

PMID29107538
PMCPMC5722659

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.