Evidence map›Paper›PMID 29107450›Full record

ArticleEpilepsy & behavior : E&B2017

Epilepsy as a Network Disorder (1): What can we learn from other network disorders such as autistic spectrum disorder and mood disorders?

Andres M Kanner, Helen Scharfman, Nathalie Jette, Evdokia Anagnostou, Christophe Bernard, Carol Camfield, Peter Camfield, Karen Legg, Ilan Dinstein, Peter Giacobbe and 2 more

Open access · greenAbstract readConference Proceedings
In one paragraph

Article in Epilepsy & behavior : E&B, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 51 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 4 countries.

Andres M KannerDepartment of Neurology, University of Miami, Miller School of Medicine, 1120 NW 14th Street, Room #1324, Miami, FL 33136, USA. Electronic address: a.kanner@med.miami.edu.
Helen ScharfmanNew York University Langone Medical Center, New York, NY 10016, USA; The Nathan Kline Institute, Orangeburg, NY, USA.
Nathalie JetteIcahn School of Medicine at Mount Sinai, Department of Neurology, New York, NY, USA; Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
Evdokia AnagnostouBloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, 150 Kilgour Road, Toronto, ON M4G 1R8, Canada.
Christophe BernardNS - Institute de Neurosciences des Systemes, UMR INSERM 1106, Aix-Marseille Université, Equipe Physionet, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France.
Carol CamfieldDepartment of Pediatrics, Dalhousie University Halifax, Nova Scotia, Canada.
Peter CamfieldDepartment of Pediatrics, Dalhousie University Halifax, Nova Scotia, Canada.
Karen LeggDivision of Neurology, Department of Medicine, Halifax Infirmary, Halifax B3H4R2, Nova Scotia, Canada.
Ilan DinsteinDepartments of Psychology and Brain & Cognitive Sciences, Zlotowski Centre for Neuroscience, Ben-Gurion University of the Negev, Be'er Sheva, Israel.
Peter GiacobbeCentre for Mental Health, University of Toronto, University Health Network, Canada.
Alon FriedmanDepartments of Physiology and Cell Biology, Brain & Cognitive Sciences, Zlotowski Centre for Neuroscience, Ben-Gurion University of the Negev, Be'er Sheva, Israel; Departments of Medical Neuroscience and Pediatrics, Faculty of Medicine, Dalhousie University Halifax, NS, Canada.
Bernd Pohlmann-EdenBrain Repair Center, Life Science Research Institute, Dalhousie University, Room 229, PO Box 15000, Halifax, Nova Scotia B3H4R2, Canada.
Dalhousie University · CAAix-Marseille Université · FRBen-Gurion University of the Negev · ILHolland Bloorview Kids Rehabilitation Hospital · CAIcahn School of Medicine at Mount Sinai · USNYU Langone Health · USUniversity of Miami · USUniversity of Toronto · CA

Funding

The Role of Hippocampal area CA2 in EpilepsyR01NS106983 · NINDS · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI Helen E Scharfman · 2018 to 2026
$4.9M
Hyperexcitability in Alzheimer's DiseaseR01AG055328 · NIA · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI SCHARFMAN, HELEN E · 2017 to 2021
$2.0M
Hilar mossy cells and dentate gyrus functionR01MH109305 · NIMH · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI SCHARFMAN, HELEN E · 2016 to 2020
$2.0M
Diverse Roles of Adult Dentate Gyrus NeurogenesisR01NS081203 · NINDS · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI SCHARFMAN, HELEN E · 2013 to 2017
$1.8M
NIA NIH HHS R01 AG055328NIMH NIH HHS R01 MH109305NINDS NIH HHS R01 NS081203NINDS NIH HHS R01 NS106983
6 · The paper itself

Abstract

Epilepsy is a neurologic condition which often occurs with other neurologic and psychiatric disorders. The relation between epilepsy and these conditions is complex. Some population-based studies have identified a bidirectional relation, whereby not only patients with epilepsy are at increased risk of suffering from some of these neurologic and psychiatric disorders (migraine, stroke, dementia, autism, depression, anxiety disorders, Attention deficit hyperactivity disorder (ADHD), and psychosis), but also patients with these conditions are at increased risk of suffering from epilepsy. The existence of common pathogenic mechanisms has been postulated as a potential explanation of this phenomenon. To reassess the relationships between neurological and psychiatric conditions in general, and specifically autism, depression, Alzheimer's disease, schizophrenia, and epilepsy, a recent meeting brought together basic researchers and clinician scientists entitled "Epilepsy as a Network Disorder." This was the fourth in a series of conferences, the "Fourth International Halifax Conference and Retreat". This manuscript summarizes the proceedings on potential relations between Epilepsy on the one hand and autism and depression on the other. A companion manuscript provides a summary of the proceedings about the relation between epilepsy and Alzheimer's disease and schizophrenia, closed by the role of translational research in clarifying these relationships. The review of the topics in these two manuscripts will provide a better understanding of the mechanisms operant in some of the common neurologic and psychiatric comorbidities of epilepsy.

Indexed as

Autistic DisorderEpilepsyHumansMood DisordersAutistic spectrum disorderCortisolGlutamateMajor depressionStress

Identifiers

PMID29107450
PMCPMC9835466
OpenAlexW2766742649

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.