Evidence map›Paper›PMID 29107136›Full record

ArticleThe Journal of nutritional biochemistry2018

Maternal hypercholesterolemia enhances oxysterol concentration in mothers and newly weaned offspring but is attenuated by maternal phytosterol supplementation.

Jerad H Dumolt, Sandhya K Radhakrishnan, Mohammed H Moghadasian, Khuong Le, Mulchand S Patel, Richard W Browne, Todd C Rideout

Open access · greenAbstract read
In one paragraph

Article in The Journal of nutritional biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Oxysterols as Biomarkers of Aging and Disease.Advances in experimental medicine and biology · 2024
    Article
  3. Journal of experimental pharmacology · 2024
    Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Jerad H DumoltDepartment of Exercise and Nutrition Sciences, School of Public Health and Health Professions, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA 14214.
Sandhya K RadhakrishnanDepartment of Biotechnical and Clinical Laboratory Sciences, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA 14214.
Mohammed H MoghadasianDepartment of Human Nutritional Sciences, University of Manitoba, and Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Hospital Research Centre, Winnipeg, MB, Canada, RH2 2A6.
Khuong LeDepartment of Human Nutritional Sciences, University of Manitoba, and Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Hospital Research Centre, Winnipeg, MB, Canada, RH2 2A6.
Mulchand S PatelDepartment of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA 14214.
Richard W BrowneDepartment of Biotechnical and Clinical Laboratory Sciences, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA 14214.
Todd C RideoutDepartment of Exercise and Nutrition Sciences, School of Public Health and Health Professions, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA 14214. Electronic address: rideout@buffalo.edu.
University at Buffalo, State University of New York · USSt. Boniface Hospital · CANutrition Sciences (Belgium) · BE

Funding

Cardiovascular Protection by Phytosterols in Dyslipidemic Mothers and ProgenyK01AT007826 · NCCIH · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI RIDEOUT, TODD · 2013 to 2017
$724k
NCCIH NIH HHS K01 AT007826
6 · The paper itself

Abstract

In hypercholesterolemic pregnancies, the maternal environment is characterized by excessive levels of atherogenic lipids that may increase cardiovascular disease risk in mothers and their offspring. We examined the influence of maternal hypercholesterolemia and phytosterol (PS) intervention on the concentration and metabolism of oxysterols, bioactive oxygenated cholesterol derivatives that regulate arterial health and lesion progression, in mothers and their newly weaned offspring. Twenty-one female apoE

Indexed as

AnimalsAnimals, NewbornApolipoproteins ECytokinesDietary SupplementsFemaleGene Expression RegulationHypercholesterolemiaLiverMaleMaternal Nutritional Physiological PhenomenaMice, Mutant StrainsOxysterolsPhytosterolsPlaque, AtheroscleroticPregnancyApolipoproteins ECytokinesOxysterolsPhytosterolsCholesterolMaternal programmingOffspringOxysterolsPhytosterols

Identifiers

PMID29107136
PMCPMC6317077
OpenAlexW2757323201

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.