Evidence map›Paper›PMID 29107041›Full record

ArticleArchives of physical medicine and rehabilitation2018

Lateral Corticospinal Tract Damage Correlates With Motor Output in Incomplete Spinal Cord Injury.

Andrew C Smith, Kenneth A Weber, Denise R O'Dell, Todd B Parrish, Marie Wasielewski, James M Elliott

Abstract read
In one paragraph

Article in Archives of physical medicine and rehabilitation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Observational
  8. Article
  9. Reproducible Spinal Cord Quantitative MRI Analysis with the Spinal Cord Toolbox.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024
    Review
  10. Article
  11. Article
  12. Biopsychosocial sequelae and recovery trajectories from whiplash injury following a motor vehicle collision.The spine journal : official journal of the North American Spine Society · 2023
    Article
  13. The influence of conventional TThe journal of spinal cord medicine · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andrew C SmithRegis University School of Physical Therapy, Denver, CO; Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL. Electronic address: asmith034@regis.edu.
Kenneth A WeberDepartment of Anesthesia, Perioperative and Pain Medicine, Stanford University, Palo Alto, CA.
Denise R O'DellRegis University School of Physical Therapy, Denver, CO.
Todd B ParrishDepartment of Radiology, Northwestern University, Chicago, IL.
Marie WasielewskiDepartment of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL.
James M ElliottDepartment of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL.

Funding

Interdisciplinary Research Training in Pain and Substance Use DisordersT32DA035165 · NIDA · STANFORD UNIVERSITY · PI SEAN C MACKEY · 2013 to 2026
$7.2M
Neuromuscular Mechanisms Underlying Poor Recovery from Whiplash InjuriesR01HD079076 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI COURTNEY, D. MARK, ELLIOTT, JAMES MATTHEW · 2014 to 2018
$1.6M
Investigating Pain Processing in the Brain, Brainstem, and Spinal Cord with fMRIF32AT007800 · NCCIH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WEBER, KENNETH ARNOLD · 2012 to 2015
$198k
NCCIH NIH HHS F32 AT007800NICHD NIH HHS R01 HD079076NIDA NIH HHS T32 DA035165NINDS NIH HHS L30 NS093515
6 · The paper itself

Abstract

objectiveTo investigate the relationship between spinal cord damage and specific motor function in participants with incomplete spinal cord injury (iSCI).

designSingle-blinded, cross-sectional study design.

settingUniversity setting research laboratory.

participantsIndividuals with chronic cervical iSCI (N=14; 1 woman, 13 men; average age ± SD, 43±12y).

interventionsNot applicable.

main outcome measuresAxial T2-weighted magnetic resonance imaging (MRI) of spinal cord damage was performed in 14 participants with iSCI. Each participant's damage was processed for total damage quantification, lateral corticospinal tract (LCST) and gracile fasciculus (GF) analysis. Plantarflexion and knee extension were quantified using an isokinetic dynamometer. Walking ability was assessed using a 6-minute walk test.

resultsTotal damage was correlated with plantarflexion, knee extension, and distance walked in 6 minutes. Right LCST damage was correlated with right plantarflexion and right knee extension, while left LCST damage was correlated with left-sided measures. Right and left GF damage was not correlated with the motor output measures.

conclusionsMRI measures of spinal cord damage were correlated to motor function, and this measure appears to have spatial specificity to descending tracts, which may offer prognostic value after SCI.

Indexed as

Disability EvaluationAdultCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPrognosisPyramidal TractsSingle-Blind MethodSpinal Cord InjuriesWalkingWalk TestMagnetic resonance imagingRehabilitationSpinal cord injuries

Identifiers

PMID29107041
PMCPMC5871547

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.