Evidence map›Paper›PMID 29106998›Full record

ArticleThe Journal of allergy and clinical immunology2018

Antiapoptotic serine protease inhibitors contribute to survival of allergenic T

Mohamed H Shamji, Jeff N Temblay, Wei Cheng, Susan M Byrne, Ellen Macfarlane, Amy R Switzer, Natalia D C Francisco, Fedina Olexandra, Fabian Jacubczik, Stephen R Durham and 1 more

Open access · greenAbstract read
In one paragraph

Article in The Journal of allergy and clinical immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. NNature communications · 2023
    Article
  5. ALK fusion NSCLC oncogenes promote survival and inhibit NK cell responses viaProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  6. Current Insights on the Impact of Proteomics in Respiratory Allergies.International journal of molecular sciences · 2022
    Review
  7. Review
  8. Article
  9. Crosstalk between ILC2s and Th2 CD4Journal of immunology research · 2022
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Mohamed H ShamjiImmunomodulation and Tolerance Group, London, United Kingdom; Allergy and Clinical Immunology, Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, and the MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom.
Jeff N TemblaySection of Immunobiology, Division of Inflammation and Immunology, Department of Medicine, Faculty of Medicine, Imperial College London, London, United Kingdom.
Wei ChengSection of Immunobiology, Division of Inflammation and Immunology, Department of Medicine, Faculty of Medicine, Imperial College London, London, United Kingdom.
Susan M ByrneSection of Immunobiology, Division of Inflammation and Immunology, Department of Medicine, Faculty of Medicine, Imperial College London, London, United Kingdom.
Ellen MacfarlaneImmunomodulation and Tolerance Group, London, United Kingdom; Allergy and Clinical Immunology, Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, and the MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom.
Amy R SwitzerImmunomodulation and Tolerance Group, London, United Kingdom; Allergy and Clinical Immunology, Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, and the MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom.
Natalia D C FranciscoImmunomodulation and Tolerance Group, London, United Kingdom; Allergy and Clinical Immunology, Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, and the MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom.
Fedina OlexandraImmunomodulation and Tolerance Group, London, United Kingdom.
Fabian JacubczikSection of Immunobiology, Division of Inflammation and Immunology, Department of Medicine, Faculty of Medicine, Imperial College London, London, United Kingdom.
Stephen R DurhamImmunomodulation and Tolerance Group, London, United Kingdom; Allergy and Clinical Immunology, Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, and the MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom.
Philip G Ashton-RickardtSection of Immunobiology, Division of Inflammation and Immunology, Department of Medicine, Faculty of Medicine, Imperial College London, London, United Kingdom. Electronic address: p.ashton-rickardt@imperial.ac.uk.
Asthma UK · GBImperial College London · GB

Funding

DEVELOPMENT AND PERSISTENCE OF MEMORY T LYMPHOCYTESR01AI045108 · NIAID · UNIVERSITY OF CHICAGO · PI ASHTON-RICKARDT, PHILIP G · 2000 to 2009
$2.4M
IMMUNE TOLERANCE NETWORK-266015416-266015416N01AI015416 · NIAID · REGENTS OF THE UNIVERSITY OF C · PI BLUESTONE, JEFFREY A · 2002 to 2006
–
Medical Research Council G1000758NIAID NIH HHS N01 AI015416NIAID NIH HHS R01 AI045108Wellcome Trust
6 · The paper itself

Abstract

backgroundThe mechanisms that regulate maintenance of persistent T

objectiveThe function of serine protease inhibitor 2A (Spi2A) was studied in mouse T

methodsSpi2A-deficient T

resultsThere were lower levels of in vitro-polarized T

conclusionThe Serpins Spi2A in mice and SERPINB3 and SERPINB4 in allergic patients control the viability of T

Indexed as

AdultAllergensAnimalsAntigens, NeoplasmAntigens, PlantCells, CulturedCell SurvivalDisease Models, AnimalFemaleHumansHypersensitivityImmunologic MemoryInflammation MediatorsMaleMiceMice, Inbred C57BLAllergensAntigens, NeoplasmAntigens, PlantInflammation MediatorsRNA, Small InterferingSerpina3k protein, mouseSerpinssquamous cell carcinoma-related antigenapoptosisgrass pollen allergymemoryT(H)2 cells

Identifiers

PMID29106998
PMCPMC5920800
OpenAlexW2766920836

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.