Evidence map›Paper›PMID 29106953›Full record

ArticleEnvironmental research2018

The association between p,p'-DDE levels and left ventricular mass is mainly mediated by obesity.

M A La Merrill, P M Lind, S Salihovic, B van Bavel, L Lind

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Cardiotoxicity of some pesticides and their amelioration.Environmental science and pollution research international · 2021
    Review
  5. Article
  6. Article
  7. Article
  8. Agrochemicals and obesity.Molecular and cellular endocrinology · 2020
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

M A La MerrillDepartment of Environmental Toxicology, University of California, Davis, CA, USA. Electronic address: mlamerrill@ucdavis.edu.
P M LindDepartment of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden. Electronic address: monica.lind@medsci.uu.se.
S SalihovicDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden; MTM Research Centre, School of Science and Technology, Örebro University, Örebro, Sweden, and Norwegian Institute for Water Research, NIVA, Oslo, Norway. Electronic address: samira.salihovic@medsci.uu.se.
B van BavelMTM Research Centre, School of Science and Technology, Örebro University, Örebro, Sweden, and Norwegian Institute for Water Research, NIVA, Oslo, Norway. Electronic address: bert.vanbavel@oru.se.
L LindDepartment of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden. Electronic address: lars.lind@medsci.uu.se.
Uppsala University · SENorwegian Institute for Water Research · NOÖrebro University · SEUniversity of California, Davis · US

Funding

UC Davis Environmental Health Sciences Core CenterP30ES023513 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Irva Hertz-Picciotto · 2015 to 2026
$26.0M
Perinatal Exposure to Environmental DDT and Risk of Metabolic SyndromeR00ES019919 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LA MERRILL, MICHELE A · 2013 to 2015
$740k
Perinatal Exposure to Environmental DDT and Risk of Metabolic SyndromeK99ES019919 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LA MERRILL, MICHELE A · 2011 to 2012
$191k
NIEHS NIH HHS K99 ES019919NIEHS NIH HHS P30 ES023513NIEHS NIH HHS R00 ES019919
6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe pesticide metabolite p,p'-DDE has been associated with left ventricular (LV) mass and known risk factors for LV hypertrophy in humans and in experimental models. We hypothesized that the associations of p,p'-DDE with LV hypertrophy risk factors, namely elevated glucose, adiposity and hypertension, mediate the association of p,p'-DDE with LV mass.

methodsp,p'-DDE was measured in plasma from 70-year-old subjects (n = 988) of the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS). When these subjects were 70-, 75- and 80- years old, LV characteristics were measured by echocardiography, while fasting glucose, body mass index (BMI) and blood pressure were assessed with standard clinical techniques.

resultsWe found that p,p'-DDE levels were associated with increased fasting glucose, BMI, hypertension and LV mass in separate models adjusted for sex. Structural equation modeling revealed that the association between p,p'-DDE and LV mass was almost entirely mediated by BMI (70%), and also by hypertension (19%).

conclusionThe obesogenic effect of p,p'-DDE is a major determinant responsible for the association of p,p'-DDE with LV mass.

Indexed as

AdiposityAgedAged, 80 and overBlood GlucoseCohort StudiesDichlorodiphenyl DichloroethyleneEnvironmental PollutantsFemaleHeart VentriclesHumansHypertensionHypertrophy, Left VentricularInsecticidesMaleObesityPrevalenceBlood GlucoseDichlorodiphenyl DichloroethyleneEnvironmental PollutantsInsecticidesGlucoseHypertensionLeft ventricular hypertrophyObesityP,p′-DDE

Identifiers

PMID29106953
PMCPMC6377158
OpenAlexW2766155938

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.