Evidence map›Paper›PMID 29106696›Full record

ReviewImmunology2018

The mechanisms shaping the repertoire of CD4

Piotr Kraj, Leszek Ignatowicz

Open access · bronzeAbstract readReview
In one paragraph

Review in Immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 29 citations in OpenAlex.

  1. Increased Nur77 is disconnected from TCR affinity in insulin-specific Tregs.Journal of immunology (Baltimore, Md. : 1950) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Piotr KrajDepartment of Biological Sciences, Old Dominion University, Norfolk, VA, USA.
Leszek IgnatowiczInstitute for Biomedical Sciences, Program in Translational Immunology, Georgia State University, Atlanta, GA, USA.ORCID 0000-0001-8666-0381
Georgia State University · USOld Dominion University · US

Funding

Modulation of regulatory cell function in cancer immunotherapyR01CA151550 · NCI · OLD DOMINION UNIVERSITY · PI KRAJ, PIOTR J. · 2011 to 2015
$1.5M
Role of CD4+T cells in maintenance of intestinal homeostasisR01DK099264 · NIDDK · GEORGIA STATE UNIVERSITY · PI IGNATOWICZ, LESZEK · 2014 to 2017
$1.3M
Diversity of intraepithelial CD8aa T cells that recognize antignes from commensal floraR21AI124056 · NIAID · GEORGIA STATE UNIVERSITY · PI IGNATOWICZ, LESZEK · 2016 to 2017
$417k
NCI NIH HHS R01 CA151550NIAID NIH HHS R21 AI124056NIDDK NIH HHS R01 DK099264
6 · The paper itself

Abstract

Regulatory T (Treg) cells expressing Foxp3 transcription factor control homeostasis of the immune system, antigenic responses to commensal and pathogenic microbiota, and immune responses to self and tumour antigens. The Treg cells differentiate in the thymus, along with conventional CD4

Indexed as

AnimalsAntigensCD4-Positive T-LymphocytesForkhead Transcription FactorsHomeostasisMajor Histocompatibility ComplexReceptors, Antigen, T-CellT-Lymphocytes, RegulatoryAntigensForkhead Transcription FactorsReceptors, Antigen, T-Cellregulation/suppressionT cellT-cell receptors

Identifiers

PMID29106696
PMCPMC5795179
OpenAlexW2767563105

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.