ReviewToxicological sciences : an official journal of the Society of Toxicology2018
Metabolic Syndrome and Associated Diseases: From the Bench to the Clinic.
Review in Toxicological sciences : an official journal of the Society of Toxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06158152 (A Randomized, Double-blind, Placebo-controlled Pilot Study to Evaluate the Systemic Effect on Immunoinflammatory and Metabolic Status of an Oral Supplementation With AM3 in Patients With Metabolic Syndrome.), which is not on this map. Cited by 107 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized, Double-blind, Placebo-controlled Pilot Study to Evaluate the Systemic Effect on Immunoinflammatory and Metabolic Status of an Oral Supplementation With AM3 in Patients With Metabolic Syndrome.
Who cites it
107 citing papers in PubMed, 2 syntheses or guidelines pooled it, 254 citations in OpenAlex.
- Prevalence of metabolic syndrome and its association with selected factors among people with psychiatric conditions in Ethiopia: a systematic review and meta-analysis.BMC public health · 2025Pooled it
- Dietary inflammatory index and its association with risk of metabolic syndrome and its components: a systematic review and Meta-analysis of Observational studies.Journal of health, population, and nutrition · 2024Pooled it
- The Effect of Chromium Picolinate Supplementation on Cardiometabolic Biomarkers, Tumor Necrosis Factor-α Gene Expression, and DNA Damage in Subjects with Metabolic Syndrome: a Randomized Placebo-Controlled Clinical Trial.Biological trace element research · 2026Trial
- The Antimicrobial Activity ofMolecules (Basel, Switzerland) · 2021Trial
- Promoter methylation of TXNIP and ADRB3 genes: potential blood-based biomarkers for metabolic syndrome.Molecular biology reports · 2026Article
- Metabolic syndrome and its risk factors among adults living with HIV receiving antiretroviral therapy in Zambia: an ambidirectional cohort study.Scientific reports · 2026Article
- Roles of metabolic dysregulation in osteoarthritis.Frontiers in cell and developmental biology · 2026Review
- Association Between Metabolic Score for Insulin Resistance (METS-IR) and Risk of Infertility: Evidence from NHANES 2013-2020 and Mendelian Randomization Study.International journal of women's health · 2026Article
- Association between Remnant Cholesterol and Metabolic Syndrome beyond Conventional Lipid Parameters in Middle Age and Elderly Population: Bushehr Elderly Health (BEH) cohort.Journal of diabetes and metabolic disorders · 2025Article
- The pathogenic theory of homeostasis threshold deviation (HTD) in wide-range oscillatory physiological parameters: novel perspectives for hypertension and metabolic disease treatment.Life metabolism · 2025Review
- Early-life thymectomy results in visceral adipose tissue inflammation and glucose intolerance.Immunity & ageing : I & A · 2025Article
- Telomere length and telomerase activity in men and non-pregnant women with and without metabolic syndrome: a systematic review and bootstrapped meta-analysis.Journal of diabetes and metabolic disorders · 2025Review
- Multitissue single-cell analysis reveals differential cellular and molecular sensitivity between fructose and high-fat high-sucrose diets.Cell reports · 2025Article
- What are the effects of time-restricted eating upon metabolic health outcomes in individuals with metabolic syndrome: A scoping review.Physiological reports · 2025Article
- Increased odds of metabolic syndrome among adults with depressive symptoms or antidepressant use.Translational psychiatry · 2025Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Estimated glucose disposal rate and risk of metabolic syndrome: A population-based study.PloS one · 2025Article
- Metabolic syndrome: risk factors and molecular drug targets.EXCLI journal · 2025Review
- Caveolin Gene, a Possible Risk Factor for Metabolic Syndrome in Humans: A Systematic Review and Meta-Analysis.International journal of preventive medicine · 2025Review
- Association between body roundness index and metabolic syndrome in middle-aged and older adults: a prospective cohort study in China.Frontiers in public health · 2025Article
47 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 10 institutions in 2 countries.
Funding
Abstract
Metabolic Syndrome and Associated Diseases: From the Bench to the Clinic, a Society of Toxicology Contemporary Concepts in Toxicology (CCT) workshop was held on March 11, 2017. The meeting was convened to raise awareness of metabolic syndrome and its associated diseases and serve as a melting pot with scientists of multiple disciplines (eg, toxicologists, clinicians, regulators) so as to spur research and understanding of this condition. The criteria for metabolic syndrome include obesity, dyslipidemia (low high-density lipoprotein and/or elevated triglycerides), elevated blood pressure, and alterations in glucose metabolism. It can lead to a greater potential of type 2 diabetes, lipid disorders, cardiovascular disease, hepatic steatosis, and other circulatory disorders. Although there are no approved drugs specifically for this syndrome, many drugs target diseases associated with this syndrome thus potentially increasing the likelihood of drug-drug interactions. There is currently significant research focusing on understanding the key pathways that control metabolism, which would be likely targets of risk factors (eg, exposure to xenobiotics, genetics) and lifestyle factors (eg, microbiome, nutrition, and exercise) that contribute to metabolic syndrome. Understanding these pathways could also lead to the development of pharmaceutical interventions. As individuals with metabolic syndrome have signs similar to that of toxic responses (eg, oxidative stress and inflammation) and organ dysfunction, these alterations should be taken into account in drug development. With the increasing frequency of metabolic syndrome in the general population, the idea of a "normal" individual may need to be redefined. This paper reports on the substance and outcomes of this workshop.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.