ArticleNucleic acids research2018
TADB 2.0: an updated database of bacterial type II toxin-antitoxin loci.
Article in Nucleic acids research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 152 papers, 1 of them a synthesis that pooled it.
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152 citing papers in PubMed, 1 synthesis or guideline pooled it, 239 citations in OpenAlex.
- A Systematic Overview of Type II and III Toxin-Antitoxin Systems with a Focus on Druggability.Toxins · 2018Pooled it
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- Persistence mechanisms of Crohn's disease-associated adherent invasiveGut microbes · 2025Article
- In silico approaches for discovering microbial antiviral defense systems.Briefings in bioinformatics · 2025Review
- Overexpression of Scr1 protein induces strong changes in the transcriptome and metabolome of Streptomyces coelicolor that affect antibiotic production.Microbial cell factories · 2025Article
- Toxin data quality: a critical examination of bacterial exotoxins and animal toxins.BMC research notes · 2025Article
- Insights into the taxonomy and virulence-related genetic profiles in 97 Cupriavidus strains through comparative genomic analysis.BMC genomics · 2025Article
- A bacterial toxin-antitoxin system involved in an unusual response to genotoxic stress.EMBO reports · 2025Article
- Bacterial programmed cell death and toxin-antitoxin system in bacteria.Archives of microbiology · 2025Review
- The Characterization of a Gonococcal HicAB Toxin-Antitoxin System Capable of Causing Bacteriostatic Growth Arrest.Microorganisms · 2025Article
- The VapBC-4 Characterization Indicates It Is a Bona Fide Toxin-Antitoxin Module ofMicroorganisms · 2025Article
- Evidence for a Functional HipBA Toxin-Antitoxin System inInternational journal of molecular sciences · 2025Article
- Enhanced suppression ofAntimicrobial agents and chemotherapy · 2025Article
- RES-Xre toxin-antitoxin locusEmerging microbes & infections · 2024Article
- Exploring antibiotic-induced persister formation and bacterial persistence genes in clinical isolates from Burkina Faso.BMC infectious diseases · 2024Article
- Dual bacteriocin and extracellular vesicle-mediated inhibition ofApplied and environmental microbiology · 2024Article
- Identification and characterization of a novel type II toxin-antitoxin system in Aeromonas veronii.Archives of microbiology · 2024Article
92 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
TADB2.0 (http://bioinfo-mml.sjtu.edu.cn/TADB2/) is an updated database that provides comprehensive information about bacterial type II toxin-antitoxin (TA) loci. Compared with the previous version, the database refined and the new data schema is employed. With the aid of text mining and manual curation, it recorded 6193 type II TA loci in 870 replicons of bacteria and archaea, including 105 experimentally validated TA loci. In addition, the newly developed tool TAfinder combines the homolog searches and the operon structure detection, allowing the prediction for type II TA pairs in bacterial genome sequences. It also helps to investigate the genomic context of predicted TA loci for putative virulence factors, antimicrobial resistance determinants and mobile genetic elements via alignments to the specific public databases. Additionally, the module TAfinder-Compare allows comparing the presence of the given TA loci across the close relative genomes. With the recent updates, TADB2.0 might provide better support for understanding the important roles of type II TA systems in the prokaryotic life activities.
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